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Lincosamides, Oxazolidinones, and Streptogramins

By Hans P. Schlecht, MD, MSc, Assistant Professor of Medicine, Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of Medicine
Christopher Bruno, MD, Assistant Professor of Medicine, Division of infectious Diseases & HIV Medicine, Drexel University College of Medicine

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Lincosamides (clindamycin—see Clindamycin), oxazolidinones (linezolid, tedizolid—see Linezolid and Tedizolid), and streptogramins (dalfopristin [streptogramin A] and quinupristin [streptogramin B]—see Quinupristin and Dalfopristin) are grouped together because they have a similar mode of antibacterial action and similar antibacterial spectra. Macrolides (see Macrolides) and the ketolide telithromycin (see Telithromycin) may be included with this group for similar reasons. All inhibit protein synthesis by binding to the 50S ribosomal subunit.

Cross-resistance occurs among the following antibiotics because they bind to the same target:

  • Macrolides

  • Clindamycin

  • Quinupristin

  • Telithromycin (to some extent)

However, cross-resistance does not occur between these antibiotics and dalfopristin and linezolid, which bind to different targets on the 50S ribosomal subunit.

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