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standards of non-Merck sources.
Pronunciation
(BEN zoe il peer OKS ide)
Generic Available (U.S.)
Yes: Excludes bar, cloth, cream, foam
Brand Names: U.S.
Brand Names: Canada
Pharmacologic Category
Pharmacologic Category Synonyms
Use: Labeled Indications
Treatment of mild-to-moderate acne vulgaris and acne rosacea
Pregnancy Risk Factor
C
Pregnancy Considerations
Animal reproduction studies have not been conducted; ~2% of the applied dose is expected to be absorbed systemically (Akhavan, 2003).
Lactation
Excretion in breast milk unknown/use caution
Contraindications
Hypersensitivity to benzoyl peroxide or any other component of the formulation.
Warnings/Precautions
Concerns related to adverse effects:
• Bleaching effects: May bleach hair, colored fabric, or carpet.
• Skin irritation: Discontinue use if severe skin irritation or redness occurs.
Other warnings/precautions:
• Appropriate use: For external use only; avoid contact with eye, eyelids, lips, and mucous membranes. Inform patients to use skin protection and minimize prolonged exposure to sun or tanning beds.
Adverse Reactions
1% to 10%: Dermatologic: Irritation, contact dermatitis, dryness, erythema, peeling, stinging
Metabolism/Transport Effects
None known.
Drug Interactions
There are no known significant interactions.
Mechanism of Action
Releases free-radical oxygen which oxidizes bacterial proteins in the sebaceous follicles decreasing the number of anaerobic bacteria and decreasing irritating-type free fatty acids
Pharmacodynamics/Kinetics
Absorption: ~5% via skin; gel more penetrating than cream
Metabolism: Converted to benzoic acid in skin
Dosage
Adolescents and Adults:
Topical formulations: Apply sparingly once daily; gradually increase to 2-3 times/day if needed. If excessive dryness or peeling occurs, reduce dose frequency or concentration. If excessive stinging or burning occurs, remove with mild soap and water; resume use the next day.
Topical cleansers: Wash once or twice daily; control amount of drying or peeling by modifying dose frequency or concentration.
Dental Health: Effects on Dental Treatment
No significant effects or complications reported
Dental Health: Vasoconstrictor/Local Anesthetic Precautions
No information available to require special precautions
Mental Health: Effects on Mental Status
None reported
Mental Health: Effects on Psychiatric Treatment
None reported
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Aerosol, foam, topical [emollient-based]:
BenzEFoam™: 5.3% (60 g)
Bar, topical [wash]:
PanOxyl® Bar: 5% (113 g [DSC]); 10% (113 g)
Zapzyt®: 10% (113 g)
Cloth, topical [cleanser]:
Triaz®: 3% (60s); 6% (60s)
Cream, topical:
BenzaShave®: 5% (113.4 g); 10% (113.4 g) [contains coconut, coconut acid]
Clearskin: 10% (28 g)
Neutrogena® On The Spot® Acne Treatment: 2.5% (22.5 g) [tinted]
Neutrogena® On The Spot® Acne Treatment: 2.5% (22.5 g) [vanishing]
ZoDerm®: 4.5% (125 mL); 6.5% (125 mL); 8.5% (125 mL) [contains urea 10%]
Cream, topical [cleanser/mask]:
Neutrogena® Clear Pore™: 3.5% (125 mL)
Gel, topical: 5% (45 g, 60 g); 10% (45 g, 60 g)
5 Benzagel®: 5% (45 g) [contains ethanol 14%]
10 Benzagel®: 10% (45 g) [contains ethanol 14%]
Acne Clear Maximum Strength: 10% (42.5 g)
BPO: 4% (42.5 g); 8% (42.5 g)
Clinac® BPO: 7% (45 g)
Zapzyt®: 10% (30 g)
ZoDerm®: 4.5% (125 mL); 6.5% (125 mL); 8.5% (125 mL) [contains urea 10%]
Gel, topical [alcohol based]: 5% (60 g [DSC]); 10% (60 g)
Gel, topical [cleanser]: 3% (170 g, 340 g); 6% (170 g, 340 g); 9% (170 g, 340 g)
Triaz®: 3% (170 g, 340 g); 6% (170 g, 340 g); 9% (170 g, 340 g)
Gel, topical [wash]: 5% (150 g, 240 g); 10% (150 g, 240 g)
Gel, topical [water based]: 2.5% (60 g); 5% (60 g, 90 g); 10% (60 g, 90 g)
Benzac® AC: 5% (60 g); 10% (60 g)
Benziq™: 5.25% (50 g) [contains aloe, benzyl alcohol]
PanOxyl® Aqua Gel: 10% (42.5 g [DSC])
Liquid, topical [cleanser]:
BP Cleanser: 4.25% (480 g) [contains aloe]
Liquid, topical [wash]: 2.5% (240 mL); 5% (120 mL, 150 mL, 240 mL)
OXY®: 10% (177 mL)
OXY® Chill Factor®: 10% (177 mL) [contains menthol]
ZoDerm® Hydrating Wash™: 5.75% (473 mL) [contains urea 10%]
Liquid, topical [wash/water based]:
Benzac® AC: 5% (240 mL); 10% (240 mL)
Benzac® W: 5% (240 mL); 10% (240 mL)
Benziq™: 5.25% (175 g) [contains aloe, benzyl alcohol]
Desquam-X® 5: 5% (140 g)
Desquam-X® 10: 10% (140 g)
Lotion, topical: 5% (30 mL); 10% (30 mL)
OXY®: 5% (28 g) [vanishing]
OXY®: 10% (28 g) [tinted]
OXY®: 10% (28 g) [vanishing]
Palmer's® Skin Success Invisible Acne: 10% (30 mL) [contains aloe, vitamin E]
Lotion, topical [wash]: 5% (227 g); 10% (227 g)
BP Cleansing Lotion: 4% (297 g)
Pacnex™: 7% (480 mL) [contains aloe]
Pad, topical: 3% (30s); 4.5% (30s); 6% (30s); 6.5% (30s); 8.5% (30s); 9% (30s)
Inova™: 4% (30s); 8% (30s)
Triaz®: 3% (30s, 60s); 6% (30s, 60s); 9% (30s, 60s)
ZoDerm® Redi-Pads™: 4.5% (30s); 6.5% (30s); 8.5% (30s) [contains urea 10%]
Soap, topical [cleanser/emulsion-based]: 4.5% (400 mL); 6.5% (400 mL); 8.5% (400 mL)
ZoDerm®: 4.5% (400 mL); 6.5% (400 mL); 8.5% (400 mL) [contains urea 10%]
Wash, topical: 2.5% (227 g); 5% (113 g, 142 g, 227 g); 10% (142 g, 227 g)
BP Wash: 5.25% (175 g) [contains aloe, benzyl alcohol]
Lavoclen® Acne Wash Kit: 4% (1s); 8% (1s) [kit includes soap free cleanser lotion]
Lavoclen™-4: 4% (170 g)
Lavoclen™-8: 8% (170 g)
PanOxyl®-4: 4% (170 g) [contains castor oil]
PanOxyl®-8: 8% (170 g) [contains castor oil]
PanOxyl®: 10% (156 g) [contains castor oil]
Pricing: U.S. (www.drugstore.com)
Cream (Benzashave)
10% (113.4): $105.99
Cream (Zoderm)
4.5-10% (125): $231.99
Foam (BenzEFoam)
5.3% (60): $193.59
Gel (Benzac AC)
10% (60): $111.07
Gel (Benzoyl Peroxide)
2.5% (60): $24.99
5% (42.5): $13.99
5% (60): $24.99
5% (90): $26.99
10% (42.5): $13.98
10% (60): $25.99
10% (90): $29.99
Gel (Clinac BPO)
7% (45): $105.99
Gel (Zoderm)
4.5-10% (125): $231.98
Kit (Lavoclen-4 Acne Wash)
4% (1): $49.99
Liquid (Benziq Wash)
5.25% (175): $88.75
Liquid (Benzoyl Peroxide Wash)
2.5% (227): $29.99
Liquid (Lavoclen-4 Creamy Wash)
4% (170.1): $55.99
Liquid (Zoderm Cleanser)
6.5-10% (400): $157.99
8.5-10% (400): $166.61
Misc (Triaz Foaming Cloths)
6% (60): $355.99
Pads (Benzoyl Peroxide)
3% (30): $139.99
Pads (Triaz)
3% (30): $209.99
6% (30): $209.99
6% (60): $395.99
9% (30): $209.99
Pads (Zoderm)
4.5-10% (30): $169.98
6.5-10% (30): $172.99
References
Akhavan A and Bershad S, "Topical Acne Drugs: Review of Clinical Properties, Systemic Exposure, and Safety," Am J Clin Dermatol, 2003, 4(7):473-92.
International Brand Names
Lexi-Comp.com
Last full review/revision March 2012
Content last modified March 2012
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