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Pronunciation
(NAF ti feen)
Generic Available
No
Index Terms
U.S. Brand Names
Pharmacologic Category
Pharmacologic Category Synonyms
Use: Labeled Indications
Topical treatment of tinea cruris (jock itch), tinea corporis (ringworm), and tinea pedis (athlete's foot)
Pregnancy Risk Factor
B
Pregnancy Considerations
Teratogenic events were not observed in animal studies.
Lactation
Excretion in breast milk unknown/use caution
Contraindications
Hypersensitivity to naftifine or any component of the formulation
Warnings/Precautions
Concerns related to adverse effects:
• Irritation: Discontinue if sensitivity or irritation occurs
Other warnings/precautions:
• Appropriate use: For topical use only; avoid contact with eyes, nose, mouth, or mucous membranes.
Adverse Reactions
1% to 10%:
Dermatologic: Burning/stinging (5% to 6%), erythema (≤2%), pruritus (1% to 2%)
Local: Dryness (3%), irritation (2%)
<1%: Rash, skin tenderness
Drug Interactions
There are no known significant interactions.
Mechanism of Action
Synthetic, broad-spectrum antifungal agent in the allylamine class; appears to have both fungistatic and fungicidal activity. Exhibits antifungal activity by selectively inhibiting the enzyme squalene epoxidase in a dose-dependent manner which results in a reduced synthesis of ergosterol, the primary sterol within the fungal membrane.
Pharmacodynamics/Kinetics
Absorption: Systemic: Cream: 6%; Gel: ≤4%
Half-life elimination: 2-3 days
Excretion: Urine and feces (as unchanged drug and/or metabolites)
Dosage
Adults: Topical: Apply cream once daily and gel twice daily (morning and evening) for up to 4 weeks
Geriatric Considerations
No specific recommendations for use in the elderly.
Dental Health: Effects on Dental Treatment
No significant effects or complications reported
Dental Health: Vasoconstrictor/Local Anesthetic Precautions
No information available to require special precautions
Mental Health: Effects on Mental Status
None reported
Mental Health: Effects on Psychiatric Treatment
None reported
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Cream, topical, as hydrochloride:
Naftin®: 1% (30 g, 60 g, 90 g) [contains benzyl alcohol]
Gel, topical, as hydrochloride:
Naftin®: 1% (40 g, 60 g, 90 g) [contains ethanol 52%]
Pricing: U.S. (www.drugstore.com)
Cream (Naftin)
1% (30): $109.99
1% (60): $190.00
1% (90): $239.98
Gel (Naftin)
1% (40): $155.99
1% (60): $216.00
1% (90): $269.99
International Brand Names
Lexi-Comp.com
Last full review/revision January 2011
Content last modified January 2011
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