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standards of non-Merck sources.
Pronunciation
(pra MOKS een)
Generic Available (U.S.)
Yes: Foam
Index Terms
Brand Names: U.S.
Pharmacologic Category
Pharmacologic Category Synonyms
Use: Labeled Indications
Temporary relief of pain and itching associated with hemorrhoids, burns, minor cuts, scrapes, or minor skin irritations
Warnings/Precautions
Other warnings/precautions:
• Self-medication (OTC use): For external use only. When used for self-medication, notify healthcare provider if condition worsens or does not improve within 7 days; clears up and occurs again within a few days; or if accompanied by additional symptoms (eg, swelling, rash, irritation). Do not use topical products on open wounds or large areas of the body; avoid contact with the eyes and nose.
Metabolism/Transport Effects
None known.
Drug Interactions
There are no known significant interactions.
Mechanism of Action
Pramoxine, like other anesthetics, decreases the neuronal membrane's permeability to sodium ions; both initiation and conduction of nerve impulses are blocked, thus depolarization of the neuron is inhibited
Pharmacodynamics/Kinetics
Onset of action: 3-5 minutes
Dosage
Topical:
Children ≥2 years and Adults: Minor skin irritation: Lotion, cream: Apply to affected area up to 3-4 times/day
Children ≥12 years and Adults:
Hemorrhoidal itching: Foam, ointment: Apply to affected area up to 5 times/day
Vaginal itching: Wipes: Gently pat or wipe external vaginal area up to 3-4 times/day
Administration: Topical
Cream: Do not apply in or around the eyes.
Lotion: Apply sparingly, use the minimal effective dose.
Foam: Shake well. Cleanse and dry area prior to use. Dispense foam onto a clean tissue and apply externally. Do not insert into rectum.
Ointment: Do not insert into rectum.
Wipes: Unfold towelette; gently pat or wipe external vaginal area from front to back; discard towelette after 1 use.
Dental Health: Effects on Dental Treatment
No significant effects or complications reported
Dental Health: Vasoconstrictor/Local Anesthetic Precautions
No information available to require special precautions
Mental Health: Effects on Mental Status
None reported
Mental Health: Effects on Psychiatric Treatment
None reported
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Aerosol, foam, topical, as hydrochloride: 1% (15 g [DSC])
Proctofoam® NS: 1% (15 g)
Cloth, topical:
Summer's Eve® Anti-Itch Maximum Strength: 1% (12s)
Cream, topical, as hydrochloride:
Dermarest® Eczema Medicated Moisturizer: 1% (56.6 g) [contains aloe, ethanol, zinc]
Tronolane® Cream: 1% (30 g, 57 g) [contains zinc oxide 5%]
Gel, topical, as hydrochloride:
Itch-X®: 1% (35.4 g) [contains aloe, benzyl alcohol]
Summer's Eve® Anti-Itch Maximum Strength: 1% (30 mL) [contains glycerin 39%]
Liquid, topical, as hydrochloride:
Curasore®: 1% (15 mL) [contains ethanol]
Lotion, topical, as hydrochloride:
Caladryl® Clear™: 1% (177 mL) [contains zinc]
Callergy Clear: 1% (177 mL) [contains zinc]
Prax®: 1% (15 mL, 120 mL, 240 mL)
Sarna® Sensitive: 1% (222 mL)
Ointment, rectal, as hydrochloride:
Tucks® Hemorrhoidal: 1% (28.3 g) [contains mineral oil, zinc oxide 12.5%]
Solution, topical, as hydrochloride [spray]:
Itch-X®: 1% (60 mL) [contains aloe, benzyl alcohol]
Soothing Care™ Itch Relief: 1% (74 mL) [contains aloe, vitamin E]
Pricing: U.S. (www.drugstore.com)
Foam (Proctofoam)
1% (15): $45.13
International Brand Names
Lexi-Comp.com
Last full review/revision January 2012
Content last modified January 2012
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