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Pronunciation

(pra MOKS een)

Generic Available (U.S.)

Yes: Aerosol, lotion

Index Terms

• Pramoxine Hydrochloride

U.S. Brand Names

• Caladryl® Clear™ [OTC]
• Callergy Clear [OTC]
• Curasore® [OTC]
• Itch-X® [OTC]
• Prax® [OTC]
• Proctofoam® NS [OTC]
• Sarna® Sensitive [OTC]
• Sarna® Ultra [OTC]
• Soothing Care™ Itch Relief [OTC]
• Summer's Eve® Anti-Itch Maximum Strength [OTC]
• Tronolane® Cream [OTC]
• Tucks® Hemorrhoidal [OTC]

Pharmacologic Category

• Local Anesthetic

Pharmacologic Category Synonyms

• Anesthetic, Local

Use: Labeled Indications

Temporary relief of pain and itching associated with anogenital pruritus or irritation; dermatosis, minor burns, or hemorrhoids

Pregnancy Risk Factor

C

Adverse Reactions

1% to 10%:

Dermatologic: Angioedema

Local: Contact dermatitis, burning, stinging

<1%: Edema, methemoglobinemia in infants, urethritis, urticaria, tenderness

Drug Interactions

There are no known significant interactions.

Mechanism of Action

Pramoxine, like other anesthetics, decreases the neuronal membrane's permeability to sodium ions; both initiation and conduction of nerve impulses are blocked, thus depolarization of the neuron is inhibited

Pharmacodynamics/Kinetics

Onset of action: Therapeutic: 2-5 minutes

Peak effect: 3-5 minutes

Duration: Several days

Dosage

Adults: Topical: Apply as directed, usually 3-5 times daily to affected area

Administration: Topical

Apply sparingly, use the minimal effective dose.

Dental Health: Effects on Dental Treatment

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions

No information available to require special precautions

Mental Health: Effects on Mental Status

None reported

Mental Health: Effects on Psychiatric Treatment

None reported

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Aerosol, topical, as hydrochloride [foam]: 1% (15 g)

Proctofoam® NS: 1% (15 g)

Cloth, topical:

Summer's Eve® Anti-Itch Maximum Strength: 1% (12s)

Cream, topical, as hydrochloride:

Sarna® Ultra: 1% (56.6 g) [contains menthol]

Tronolane® Cream: 1% (30 g, 57 g) [contains zinc oxide 5%]

Gel, topical, as hydrochloride:

Itch-X®: 1% (35.4 g) [contains aloe, benzyl alcohol]

Summer's Eve® Anti-Itch Maximum Strength: 1% (30 mL) [contains glycerin 39%]

Liquid, topical, as hydrochloride:

Curasore®: 1% (15 mL) [contains ethanol]

Lotion, topical, as hydrochloride:

Caladryl® Clear™: 1% (177 mL) [contains zinc]

Callergy Clear: 1% (177 mL) [contains zinc]

Prax®: 1% (15 mL, 120 mL, 240 mL)

Sarna® Sensitive: 1% (222 mL)

Ointment, rectal, as hydrochloride:

Tucks® Hemorrhoidal: 1% (28.3 g) [contains mineral oil, zinc oxide 12.5%]

Solution, topical, as hydrochloride [spray]:

Itch-X®: 1% (60 mL) [contains aloe, benzyl alcohol]

Soothing Care™ Itch Relief: 1% (74 mL) [contains aloe, vitamin E]

Pricing: U.S. (www.drugstore.com)

Foam (Proctofoam)

1% (15): $45.13

International Brand Names

• Anugesic (ZA)
• Nestosyl (NL)
• Primoly Gel (TH)
• Sarmed (IL)
• Tronotene (IT)
• Tronothane (FR)

Lexi-Comp.com

Last full review/revision March 2011

Content last modified March 2011