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standards of non-Merck sources.
Pronunciation
(trye FLURE i deen)
Generic Available (U.S.)
Yes
Index Terms
U.S. Brand Names
Canadian Brand Names
Pharmacologic Category
Pharmacologic Category Synonyms
Use: Labeled Indications
Treatment of primary keratoconjunctivitis and recurrent epithelial keratitis caused by herpes simplex virus types I and II
Pregnancy Risk Factor
C
Lactation
Excretion in breast milk unknown
Contraindications
Hypersensitivity to trifluridine or any component of the formulation
Warnings/Precautions
Special handling:
• Hazardous agent: Use appropriate precautions for handling and disposal.
Concerns related to adverse effects:
• Irritation: Mild local irritation of conjunctival and cornea may occur when instilled but usually transient effects.
Adverse Reactions
1% to 10%: Local: Burning, stinging
<1%: Epithelial keratopathy, hyperemia, hypersensitivity reactions, intraocular pressure increased, keratitis, palpebral edema, stromal edema
Drug Interactions
There are no known significant interactions.
Storage
Refrigerate at 2°C to 8°C (36°F to 46°F). Storage at room temperature may result in a solution altered pH which could result in ocular discomfort upon administration and/or decreased potency.
Mechanism of Action
Interferes with viral replication by incorporating into viral DNA in place of thymidine, inhibiting thymidylate synthetase resulting in the formation of defective proteins
Pharmacodynamics/Kinetics
Absorption: Ophthalmic: Systemic absorption negligible, corneal penetration adequate
Dosage
Adults: Instill 1 drop into affected eye every 2 hours while awake, to a maximum of 9 drops/day, until re-epithelialization of corneal ulcer occurs; then use 1 drop every 4 hours for another 7 days; do not exceed 21 days of treatment; if improvement has not taken place in 7-14 days, consider another form of therapy
Monitoring Parameters
Ophthalmologic exam (test for corneal staining with fluorescein or rose bengal)
Patient Education
For ophthalmic use only. Tilt head back and look upward. Gently pull down lower lid and put drop(s) in inner corner of eye. Close eye and roll eyeball in all directions. Do not blink for 1/2 minute. Apply gentle pressure to inner corner of eye for 30 seconds. Wipe away excess from skin around eye. Do not use any other eye preparation for at least 10 minutes. May cause sensitivity to bright light; temporary stinging or blurred vision may occur. Inform prescriber if you experience eye pain, redness, burning, watering, dryness, double vision, puffiness around eye, vision changes, worsening of condition, or lack of improvement within 7-14 days.
Geriatric Considerations
Assess ability to self-administer.
Dental Health: Effects on Dental Treatment
No significant effects or complications reported
Dental Health: Vasoconstrictor/Local Anesthetic Precautions
No information available to require special precautions
Mental Health: Effects on Mental Status
None reported
Mental Health: Effects on Psychiatric Treatment
None reported
Nursing: Physical Assessment/Monitoring
Not for long-term use.
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, ophthalmic [drops]: 1% (7.5 mL)
Viroptic®: 1% (7.5 mL)
Pricing: U.S. (www.drugstore.com)
Solution (Trifluridine)
1% (7.5): $153.99
Solution (Viroptic)
1% (7.5): $159.99
International Brand Names
Lexi-Comp.com
Last full review/revision March 2011
Content last modified March 2011
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