THE MERCK MANUAL: The Merck Manual of Diagnosis and Therapymultimedia


  • Focal Segmental Glomerulosclerosis
  • Focal Segmental Glomerulosclerosis

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    Focal Segmental Glomerulosclerosis

    The top image shows the right side of the glomerulus. The glomerulus, which is segmentally sclerotic, is composed of obliterated capillary lumens and an increased amount of mesangial matrix. The rest of the glomerulus is normal (Jones silver stain, ×400). In the bottom image, hyalin, defined as smooth, glassy-appearing material, results from insudation of plasma proteins. It occurs frequently and is not diagnostic (Jones silver stain, ×400).

    Images provided by Agnes Fogo, MD and the American Journal of Kidney Disease's Atlas of Renal Pathology (see