THE MERCK MANUAL: The Merck Manual of Diagnosis and Therapymultimedia


  • Membranoproliferative Glomerulonephritis
  • Membranoproliferative Glomerulonephritis, Type II

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    Membranoproliferative Glomerulonephritis, Type II

    In membranoproliferative glomerulonephritis type II, C3 nephritic factor, an IgG autoantibody which functions like properdin by directly cleaving C3 to C3b, activates complement via the alternative pathway within glomerular capillary walls and mesangium. C3 deposits partially replace the basement membrane lamina densa, giving it a thickened and distinctive ribbon appearance (Jones silver stain, ×400).

    Image provided by Agnes Fogo, MD and the American Journal of Kidney Disease's Atlas of Renal Pathology (see