THE MERCK MANUAL: The Merck Manual of Diagnosis and Therapymultimedia


  • Myeloma-Related Kidney Disease
  • Myeloma Kidney

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    Myeloma Kidney

    Myeloma kidney refers to tubulointerstitial disease caused by light chain deposition and obstructive cast formation in renal tubules. Biopsy specimen demonstrates tubular casts with surrounding syncytial giant cell reaction, chronic tubulointerstitial nephritis with lymphocytic infiltrate, and fibrosis (periodic acid-Schiff stain, original magnification ×400).

    Image provided by Agnes Fogo, MD and the American Journal of Kidney Disease's Atlas of Renal Pathology (see