THE MERCK MANUAL: The Merck Manual of Diagnosis and Therapymultimedia


  • Diagnostic Tests for Skin Disorders
  • Tzanck Test

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    Tzanck Test

    With Tzanck testing, the base and sides of a vesicle are scraped with a scalpel, and the material is stained with Wright or Giemsa stain. Multinucleated giant cells are a sign of herpes simplex or herpes zoster infection.

    Image courtesy of Joe Miller via the Public Health Image Library of the Centers for Disease Control and Prevention.