THE MERCK MANUAL: The Merck Manual of Diagnosis and Therapymultimedia


  • Skin Manifestations of Internal Disease
  • Acanthosis Nigricans

    photo size: small | high

    Acanthosis Nigricans

    Acanthosis nigricans is skin thickening and pigmentation most typically developing in the axillae and nape of the neck (top); in dark-skinned people, the skin may have a leathery appearance (bottom). It is most often a skin manifestation of impaired glucose tolerance, but it may reflect internal cancer, especially if onset is rapid and distribution is widespread.

    Images provided by Thomas Habif, MD.