THE MERCK MANUAL: The Merck Manual of Diagnosis and Therapymultimedia


  • Overview of Leukemia
  • Acute Myelogenous Leukemia (AML)
  • Acute Myelogenous Leukemia Without Maturation

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    Acute Myelogenous Leukemia Without Maturation

    In acute myelogenous leukemia (AML) without maturation, the malignant blasts vary greatly in shape but are homogeneous in staining quality. The blasts contain nuclear chromatin with a characteristic ground-glass texture, pale punched-out nucleoli, and a modest amount of cytoplasm. Myeloperoxidase cytochemistry and the presence of background dysplastic myelogenous cells usually distinguish these primitive cells from lymphoblasts.

    By permission of the publisher. From Chang K, Forman S. In Atlas of Clinical Hematology. Edited by JO Armitage. Philadelphia, Current Medicine, 2004.