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Sjögren Syndrome (SS)

(Sjögren's Syndrome)

by Rula A. Hajj-ali, MD

Sjögren syndrome (SS) is a relatively common chronic, autoimmune, systemic, inflammatory disorder of unknown cause. It is characterized by dryness of the mouth, eyes, and other mucous membranes due to lymphocytic infiltration of the exocrine gland and secondary gland dysfunction. SS can affect various exocrine glands or other organs. Diagnosis is by specific criteria relating to eye, mouth, and salivary gland involvement, autoantibodies, and (occasionally) histopathology. Treatment is usually symptomatic.

SS occurs most frequently among middle-aged women. SS is classified as primary when there is no other associated disease. In about 30% of patients with autoimmune disorders such as RA, SLE, systemic sclerosis, mixed connective tissue disease, Hashimoto thyroiditis, primary biliary cirrhosis, or chronic autoimmune hepatitis, SS develops and, in such cases, is classified as secondary. Genetic associations have been found (eg, HLA-DR3 antigens in whites with primary SS).

Drugs Mentioned In This Article

  • Drug Name
    Select Trade
  • CYTOXAN (LYOPHILIZED)
  • PLAQUENIL
  • NEORAL, SANDIMMUNE
  • EVOXAC
  • ISOPTO CARPINE, PILOPINE HS, SALAGEN
  • RITUXAN
  • RAYOS

* This is a professional Version *