| Foot Manifestations of Systemic Disorders |
|
Foot Symptoms or Signs
|
Possible Cause
|
|
Pain at rest (feet elevated), relieved by dependency
|
End-stage peripheral arterial disease
|
|
Cold, red, or cyanotic feet
|
Advanced arterial ischemia
|
|
Episodically red, hot, very painful feet
|
Erythromelalgia—idiopathic (most commonly) or secondary to various disorders (eg, myeloproliferative disorders, which are rare)
|
|
Foot pain that becomes severe within seconds or possibly minutes, particularly in patients with atrial fibrillation; foot often cool
|
Embolic arterial occlusion
|
|
Cyanosis of a single toe (blue toe syndrome)
|
Thromboembolic disease due to aortic-iliac stenosis, arrhythmia, or cholesterol embolization (after coronary artery bypass or catheterization)
Warfarin therapy
|
|
Bilateral episodic digital discomfort, pallor, and cyanosis
|
Raynaud's syndrome
|
|
Bilateral painless cyanosis (in a young female)
|
Acrocyanosis
|
|
Bilateral edema
|
Renal, hepatic, or cardiac dysfunction
Drugs (eg, Ca channel blockers)
|
|
Unilateral edema
|
Deep venous thrombosis
Lymphatic obstruction
|
|
Firm nonpitting foot and leg edema
|
Lymphedema
Systemic sclerosis
|
|
Firm nonpitting edema with nodular appearance above the malleoli
|
Pretibial myxedema
|
|
Edema with hemosiderin deposition and brownish discoloration
|
Venous insufficiency
Recurrent small-vessel vasculitis
|
|
Edema of feet and toes, numbness and pain at the ankle and heel (tarsal tunnel syndrome)
|
Hypothyroidism
Relapsing symmetric seronegative synovitis (rare)
|
|
Red, dusky patches on the dorsum with flaccid bullae (necrolytic acral erythema)
|
Hepatitis C
Vasculitis
Emboli
|
|
Isolated toe swelling and deformity (sausage digits) with pain
|
Psoriatic arthritis
Reactive arthritis
Other spondyloarthropathies
Crystal-induced arthritis
|
|
Painful feet with paresthesias
|
Peripheral neuropathy (local or systemic—eg, diabetic neuropathy)
|
|
Pain or paresthesias in the leg and foot; pain in the foot and back when the leg is extended, relieved when the knee is flexed
|
Sciatica
|
|
Toe, foot, or ankle pain with warmth and redness
|
Gout
Stress fracture
|
|
Thickened (> 22 mm) heel pad as determined with x-rays or ultrasonography
|
Hyperpituitarism with acromegaly
|