Single mononeuropathies are characterized by sensory disturbances and weakness in the distribution of the affected nerve. Diagnosis is clinical but may require confirmation with electrodiagnostic tests. Treatment is directed at the cause, sometimes with splinting, NSAIDs, corticosteroid injections, and, for severe cases of nerve entrapment, surgery.
Trauma is the most common cause of acute mononeuropathy and may occur as follows:
Hemorrhage that compresses a nerve, exposure to cold or radiation, or direct tumor invasion may also cause neuropathy. Compression of a nerve may be transient (eg, caused by an activity) or fixed (eg, caused by a mass or anatomic abnormality).
Symptoms and Signs
Single mononeuropathies are characterized by pain, weakness, and paresthesias in the distribution of the affected nerve or nerves. Pure motor nerve involvement begins with painless weakness; pure sensory nerve involvement begins with sensory disturbances and no weakness.
Ulnar nerve palsy at the elbow is often caused by trauma to the nerve in the ulnar groove of the elbow by repeated leaning on the elbow or by asymmetric bone growth after a childhood fracture (tardy ulnar palsy). The ulnar nerve can also be compressed at the cubital tunnel. Compression at the level of the elbow can cause paresthesias and a sensory deficit in the 5th digit and medial half of the 4th digit; the thumb adductor, 5th digit abductor, and interosseus muscles are weak and may be atrophied. Severe chronic ulnar palsy causes a clawhand deformity. Sensory symptoms due to this syndrome are similar to those due to C8 root dysfunction secondary to cervical radiculopathy; however, radiculopathy normally affects the more proximal aspects of the C8 dermatome.
Carpal tunnel syndrome (see also Carpal Tunnel Syndrome) may be unilateral or bilateral. It results from compression of the median nerve in the volar aspect of the wrist between the transverse superficial carpal ligament and the flexor tendons of the forearm muscles. The compression causes paresthesias in the radial-palmar aspect of the hand and pain in the wrist and palm. Pain may be referred to the forearm and shoulder. Pain may be more severe at night. A sensory deficit in the palmar aspect of the first 3 fingers may follow, and the muscles that control thumb abduction and opposition may become weak and atrophied. Sensory symptoms due to this syndrome are similar to those due to C6 root dysfunction secondary to cervical radiculopathy.
Peroneal nerve palsy is usually caused by compression of the nerve against the lateral aspect of the fibular neck. It is most common among emaciated bedbound patients and thin people who habitually cross their legs. It causes footdrop (weakened dorsiflexion and eversion of the foot) and, occasionally, a sensory deficit in the anterolateral aspect of the lower leg and the dorsum of the foot or in the web space between the 1st and 2nd metatarsals. L5 radiculopathy can cause similar deficits but, unlike peroneal nerve palsy, tends to weaken hip abduction by the gluteus medius.
Radial nerve palsy (Saturday night palsy) is caused by compression of the nerve against the humerus, as when the arm is draped over the back of a chair for a long time (eg, during intoxication or deep sleep). Typical symptoms include wristdrop (weakness of the wrist and finger extensors) and sensory loss in the dorsal aspect of the first dorsal interosseous muscle. C7 radiculopathy can cause similar motor deficits.
Symptoms and examination findings may be nearly pathognomonic.
Electrodiagnostic tests are usually done to clarify the diagnosis, particularly when clinical findings are inconclusive—for example,
Electrodiagnostic tests also help localize the lesion, assess severity, and estimate prognosis.
Underlying disorders are treated. Treatment of compression neuropathy depends on cause:
Braces or splints are often used pending resolution to prevent contractures. Surgery should be considered when progression occurs despite conservative treatment.
Last full review/revision March 2014 by Michael Rubin, MDCM
updates.last-modified March 2014