There are over 200 disorders that involve connective tissue. Certain disorders are characterized by overactivity of the immune system with resulting inflammation and systemic damage to the tissues (eg, SLE [see Systemic Lupus Erythematosus (SLE)] and juvenile idiopathic arthritis [formerly known as juvenile rheumatoid arthritis—see Juvenile Idiopathic Arthritis (JIA)]). Other disorders involve biochemical abnormalities or structural defects of the connective tissue. Some of these disorders are inherited, and some are of unknown etiology.
Last full review/revision January 2014 by David D. Sherry, MD; Frank Pessler, MD, PhD
Content last modified January 2014