Attention-Deficit/Hyperactivity Disorder (ADD, ADHD)
Attention-deficit/hyperactivity disorder (ADHD) is a syndrome of inattention, hyperactivity, and impulsivity. The 3 types of ADHD are predominantly inattentive, predominantly hyperactive/impulsive, and combined. Diagnosis is made by clinical criteria. Treatment usually includes drug therapy with stimulant drugs, behavioral therapy, and educational interventions.
Attention-deficit/hyperactivity disorder is considered a neurodevelopmental disorder. Neurodevelopmental disorders are neurologically based conditions that appear early in childhood, typically before school entry, and impair development of personal, social, academic, and/or occupational functioning. They typically involve difficulties with the acquisition, retention, or application of specific skills or sets of information. Neurodevelopmental disorders may involve dysfunction in attention, memory, perception, language, problem-solving, or social interaction. Other common neurodevelopmental disorders include autism spectrum disorders, learning disorders (eg, dyslexia), and intellectual disability.
Although some experts previously considered ADHD a behavior disorder, this was probably because comorbid behavior disorders, particularly oppositional-defiant disorder and conduct disorder, are common.
ADHD affects an estimated 5 to 11% of school-aged children. However, many experts think ADHD is overdiagnosed, largely because criteria are applied inaccurately. According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), there are 3 types:
Overall, ADHD is about twice as common in boys, although the ratios vary by type. The predominantly hyperactive/impulsive type occurs 2 to 9 times more frequently in boys; the predominantly inattentive type occurs with about equal frequency in both sexes. ADHD tends to run in families.
ADHD has no known single, specific cause. Potential causes include genetic, biochemical, sensorimotor, physiologic, and behavioral factors. Some risk factors include birth weight < 1500 g, head trauma, iron deficiency, obstructive sleep apnea, and lead exposure, as well as prenatal exposure to alcohol, tobacco, and cocaine. Fewer than 5% of children with ADHD have evidence of neurologic injury. Increasing evidence implicates abnormalities in dopaminergic and noradrenergic systems with decreased activity or stimulation in upper brain stem and frontal-midbrain tracts.
Although ADHD is considered a disorder of children and always starts during childhood, it persists into adulthood in about half of cases. Although the diagnosis occasionally may not be recognized until adolescence or adulthood, some manifestations should have been present before age 12.
In adults, symptoms include
Hyperactivity in adults usually manifests as restlessness and fidgetiness rather than the overt motor hyperactivity that occurs in young children. Adults with ADHD tend to be at higher risk for unemployment, reduced educational achievement, and increased rates of substance abuse and criminality. Motor vehicle crashes and violations are more common.
ADHD can be more difficult to diagnose during adulthood. Symptoms may be similar to those of mood disorders, anxiety disorders, and substance use disorders. Because self-reporting of childhood symptoms may be unreliable, clinicians may need to review school records or interview family members to confirm existence of manifestations before age 12.
Adults with ADHD may benefit from the same types of stimulant drugs that children with ADHD take. They may also benefit from counseling to improve time management and other coping skills.
Onset often occurs before age 4 and invariably before age 12. The peak age for diagnosis is between ages 8 and 10; however, patients with the predominantly inattentive type may not be diagnosed until after adolescence.
Core symptoms and signs of ADHD involve
Inattention tends to appear when a child is involved in tasks that require vigilance, rapid reaction time, visual and perceptual search, and systematic and sustained listening.
Impulsivity refers to hasty actions that have the potential for a negative outcome (eg, in children, running across a street without looking, in adolescents and adults, suddenly quitting school or a job without thought for the consequences).
Hyperactivity involves excessive motor activity. Children, particularly younger ones, may have trouble sitting quietly when expected to (eg, in school or church). Older patients may simply be fidgety, restless, or talkative—sometimes to the extent that others feel worn out watching them.
Inattention and impulsivity impede development of academic skills and thinking and reasoning strategies, motivation for school, and adjustment to social demands. Children who have predominantly inattentive ADHD tend to be hands-on learners who have difficulty in passive learning situations that require continuous performance and task completion.
Overall, about 20 to 60% of children with ADHD have learning disabilities, but some school dysfunction occurs in most children with ADHD due to inattention (resulting in missed details) and impulsivity (resulting in responding without thinking through the question).
Behavioral history can reveal low frustration tolerance, opposition, temper tantrums, aggressiveness, poor social skills and peer relationships, sleep disturbances, anxiety, dysphoria, depression, and mood swings.
Although there are no specific physical examination or laboratory findings associated with ADHD, signs can include
Diagnosis is clinical and is based on comprehensive medical, developmental, educational, and psychologic evaluations (see also the American Academy of Pediatrics ADHD: Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents).
DSM-5 diagnostic criteria include 9 symptoms and signs of inattention and 9 of hyperactivity and impulsivity. Diagnosis using these criteria requires that ≥ 6 symptoms and signs from at least one group
Does not pay attention to details or makes careless mistakes in schoolwork or with other activities
Has difficulty sustaining attention on tasks at school or during play
Does not seem to listen when spoken to directly
Does not follow through on instructions or finish tasks
Has difficulty organizing tasks and activities
Avoids, dislikes, or is reluctant to engage in tasks that require sustained mental effort over a long period of time
Often loses things necessary for school tasks or activities
Is easily distracted
Is forgetful in daily activities
Hyperactivity and impulsivity symptoms:
Often fidgets with hands or feet or squirms
Often leaves seat in classroom or elsewhere
Often runs about or climbs excessively where such activity is inappropriate
Has difficulty playing quietly
Often on the go, acting as if driven by a motor
Often talks excessively
Often blurts out answers before questions are completed
Often has difficulty awaiting turn
Often interrupts or intrudes on others
Diagnosis of the predominantly inattentive type requires ≥ 6 symptoms and signs of inattention. Diagnosis of the hyperactive/impulsive type requires ≥ 6 symptoms and signs of hyperactivity and impulsivity. Diagnosis of the combined type requires ≥ 6 symptoms and signs each of inattention and hyperactivity/impulsivity.
Differentiating between ADHD and other conditions can be challenging. Overdiagnosis must be avoided, and other conditions must be accurately identified. Many ADHD signs expressed during the preschool years could also indicate communication problems that can occur in other neurodevelopmental disorders (eg, autism spectrum disorders) or in certain learning disorders, anxiety, depression, or behavioral disorders (eg, conduct disorder).
Clinicians should consider whether the child is distracted by external factors (ie, environmental input) or by internal factors (ie, thoughts, anxieties, worries). However, during later childhood, ADHD signs become more qualitatively distinct; children with the hyperactive/impulsive or combined types often exhibit continuous movement of the lower extremities, motor impersistence (eg, purposeless movement, fidgeting of hands), impulsive talking, and a seeming lack of awareness of their environment. Children with the predominantly inattentive type may have no physical signs.
Medical assessment focuses on identifying potentially treatable conditions that may contribute to or worsen symptoms and signs. Assessment should include seeking a history of prenatal exposures (eg, drugs, alcohol, tobacco), perinatal complications or infections, CNS infections, traumatic brain injury, cardiac disease, sleep-disordered breathing, poor appetite and/or picky eating, and a family history of ADHD.
Developmental assessment focuses on determining the onset and course of symptoms and signs. The assessment includes checking developmental milestones, particularly language milestones and the use of ADHD-specific rating scales (eg, the Vanderbilt Assessment Scale, the Conners Comprehensive Behavior Rating Scale, the ADHD Rating Scale IV).
Educational assessment focuses on documenting core symptoms and signs; it may involve reviewing educational records and using rating scales or checklists. However, rating scales and checklists alone often cannot distinguish ADHD from other developmental disorders or from behavioral disorders.
Traditional classrooms and academic activities often exacerbate symptoms and signs in children with untreated or inadequately treated ADHD. Social and emotional adjustment problems may be persistent. Poor acceptance by peers and loneliness tend to increase with age and with the obvious display of symptoms. Substance abuse may result if ADHD is not identified and adequately treated because many adolescents and adults with ADHD self-medicate with both legal (eg, caffeine) and illegal (eg, cocaine) substances.
Although hyperactivity symptoms and signs tend to diminish with age, adolescents and adults may display residual difficulties. Predictors of poor outcomes in adolescence and adulthood include
Problems in adolescence and adulthood manifest predominantly as academic failure, low self-esteem, and difficulty learning appropriate social behavior. Adolescents and adults who have predominately impulsive ADHD may have an increased incidence of personality trait disorders and antisocial behavior; many continue to display impulsivity, restlessness, and poor social skills. People with ADHD seem to adjust better to work than to academic and home situations, particularly if they can find jobs that do not require intense attention to perform.
Randomized, controlled studies show behavioral therapy alone is less effective than therapy with stimulant drugs alone for school-aged children, but behavioral or combination therapy is recommended for younger children. Although correction of the underlying neurophysiologic differences of patients with ADHD does not occur with drug therapy, drugs are effective in alleviating ADHD symptoms and they permit participation in activities previously inaccessible because of poor attention and impulsivity. Drugs often interrupt the cycle of inappropriate behavior, enhancing behavioral and academic interventions, motivation, and self-esteem.
Treatment of adults follows similar principles, but drug selection and dosing are determined on an individual basis, depending on other medical conditions.
Stimulant preparations that include methylphenidate or amphetamine salts are most widely used. Response varies greatly, and dosage depends on the severity of the behavior and the child’s ability to tolerate the drug. Dosing is adjusted in frequency and amount until the optimal response is achieved.
Methylphenidate is usually started at 0.3 mg/kg po once/day (immediate-release form) and increased in frequency weekly, usually to about 3 times per day or every 4 h. If response is inadequate but the drug is tolerated, dose can be increased. Most children find an optimal balance between benefits and adverse effects at individual doses between 0.3 and 0.6 mg/kg. The dextro isomer of methylphenidate is the active moiety and is available for prescription at one half the dose.
Dextroamphetamine is typically started (often in combination with racemic amphetamine) at 0.15 to 0.2 mg/kg po once/day, which can then be increased to 2 or 3 times per day or every 4 h. Individual doses in the range of 0.15 to 0.4 mg/kg are usually effective. Dose titration should balance effectiveness against adverse effects. In general, dextroamphetamine doses are about two thirds those of methylphenidate doses.
For methylphenidate or dextroamphetamine, once an optimal dosage is reached, an equivalent dosage of the same drug in a sustained-release form is often substituted to avoid the need for drug administration in school. Long-acting preparations include wax matrix slow-release tablets, biphasic capsules containing the equivalent of 2 doses, and osmotic release pills and transdermal patches that provide up to 12 h of coverage. Both short-acting and long-acting liquid preparations are now available. Pure dextro preparations (eg, dextromethylphenidate) are often used to minimize adverse effects such as anxiety; doses are typically half those of mixed preparations. Prodrug preparations are also sometimes used because of their smoother release, longer duration of action, fewer adverse effects, and lower abuse potential. Learning is often enhanced by low doses, but improvement in behavior often requires higher doses.
Dosing schedules of stimulant drugs can be adjusted to cover specific days and times (eg, during school hours, while doing homework). Drug holidays may be tried on weekends, on holidays, or during summer vacations. Placebo periods (for 5 to 10 school days to ensure reliability of observations) are recommended to determine whether the drugs are still needed.
Common adverse effects of stimulant drugs include
Some studies have shown slowing of growth over 2 yr of stimulant drug use, but results have not been consistent, and whether slowing persists over longer periods of use remains unclear. Some patients who are sensitive to stimulant drug effects appear overfocused or dulled; decreasing the stimulant drug dosage or trying a different drug may be helpful.
Atomoxetine, a selective norepinephrinereuptake inhibitor, is also used. The drug is effective, but data are mixed regarding its efficacy compared with stimulant drugs. Many children experience nausea, sedation, irritability, and temper tantrums; rarely, liver toxicity and suicidal ideation occur. A typical starting dose is 0.5 mg/kg po once/day, titrated weekly to 1.2 to 1.4 mg/kg once/day. The long half-life allows once/day dosing but requires continuous use to be effective. The maximum recommended daily dosage is 100 mg.
Antidepressants such as bupropion, alpha-2 agonists such as clonidine and guanfacine, and other psychoactive drugs are sometimes used in cases of stimulant drug ineffectiveness or unacceptable adverse effects, but they are less effective and are not recommended as first-line drugs. Sometimes these drugs are used in combination with stimulants for synergistic effects; close monitoring for adverse effects is essential.
Counseling, including cognitive-behavioral therapy (eg, goal-setting, self-monitoring, modeling, role-playing), is often effective and helps children understand ADHD. Structure and routines are essential.
Classroom behavior is often improved by environmental control of noise and visual stimulation, appropriate task length, novelty, coaching, and teacher proximity.
When difficulties persist at home, parents should be encouraged to seek additional professional assistance and training in behavioral management techniques. Adding incentives and token rewards reinforces behavioral management and is often effective. Children with ADHD in whom hyperactivity and poor impulse control predominate are often helped at home when structure, consistent parenting techniques, and well-defined limits are established.
Elimination diets, megavitamin treatments, use of antioxidants or other compounds, and nutritional and biochemical interventions have had the least consistent effects. Biofeedback can be helpful in some cases but is not recommended for routine use because evidence of sustained benefit is lacking.
ADHD involves inattention, hyperactivity/impulsivity, or a combination; it typically appears before age 12, including in preschoolers.
Cause is unknown, but there are numerous suspected risk factors.
Diagnose using clinical criteria, and be alert for other disorders that may initially manifest similarly (eg, autism spectrum disorders, certain learning or behavioral disorders, anxiety, or depression).
Manifestations tend to diminish with age, but adolescents and adults may have residual difficulties.
Treat with stimulant drugs and cognitive-behavioral therapy; behavioral therapy alone may be appropriate for preschool-aged children.
Drug NameSelect Trade