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Bipolar Disorder in Children and Adolescents

by Josephine Elia, MD

Bipolar disorder is characterized by alternating periods of mania, depression, and normal mood, each lasting for weeks to months at a time. Diagnosis is based on clinical criteria. Treatment is a combination of mood stabilizers (eg, lithium, certain anticonvulsants, antipsychotic drugs), psychotherapy, and antidepressants.

Bipolar disorder typically begins during mid-adolescence through the mid-20s. In many children, the initial manifestation is one or more episodes of depression.

Bipolar disorder is rare in children. In the past, bipolar disorder was diagnosed in prepubertal children who were disabled by intense, unstable moods. However, because such children typically progress to a depressive rather than bipolar disorder, they are now classified as having disruptive mood dysregulation disorder (see Disruptive mood dysregulation disorder).

Etiology

Etiology is unknown, but heredity is involved. Dysregulation of serotonin and norepinephrine may be involved, as may a stressful life event. Certain drugs (eg, cocaine, amphetamines, phencyclidines, certain antidepressants) and environmental toxins (eg, lead) can exacerbate or mimic the disorder. Certain disorders (eg, thyroid disorders) can cause similar symptoms.

Symptoms and Signs

The hallmark of bipolar disorder is the manic episode. Manic episodes alternate with depressive episodes, which can be more frequent.

During a manic episode in adolescents, mood may be very positive or hyperirritable and often alternates between the 2 moods depending on social circumstances. Speech is rapid and pressured, sleep is decreased, and self-esteem is inflated. Mania may reach psychotic proportions (eg, “I have become one with God”). Judgment may be severely impaired, and adolescents may engage in risky behaviors (eg, promiscuous sex, reckless driving). Prepubertal children may experience dramatic moods, but the duration of these moods is much shorter (often lasting only a few moments) than that in adolescents. Onset is characteristically insidious, and children typically have a history of always being very temperamental and difficult to manage.

Diagnosis

  • Clinical evaluation

  • Testing for toxicologic causes

Diagnosis is based on history and mental status examination. A number of medical disorders (eg, thyroid disorders, brain infections or tumors) and drug intoxication must be ruled out with appropriate medical assessment, including a toxicology screen for drugs of abuse and environmental toxins. The interviewer should also search for precipitating events, such as severe psychologic stress, including sexual abuse or incest.

Prognosis

Prognosis for adolescents with bipolar disorder varies. Those who have mild to moderate symptoms, who have a good response to treatment, and who remain adherent and cooperative with treatment have an excellent prognosis. However, treatment response is often incomplete, and adolescents are notoriously nonadherent to drug regimens. For such adolescents, the long-term prognosis is not as good.

Little is known about the long-term prognosis of prepubertal children diagnosed with bipolar disorder based on highly unstable and intense moods.

Treatment

  • Mood stabilizers and antidepressants

  • Psychotherapy

For adolescents and prepubertal children, mood stabilizers are used to treat manic or agitated episodes, and psychotherapy and antidepressants treat the depressive episodes.

Mood stabilizers (see Table: Selected Drugs for Bipolar Disorder*) roughly fall into 3 categories:

  • Mood-stabilizing anticonvulsants

  • Mood-stabilizing antipsychotics

  • Lithium

All mood stabilizers have a potential for troubling and even dangerous adverse effects. Thus, treatment must be individualized. Furthermore, drugs that are highly successful during initial stabilization may be unacceptable for maintenance because of adverse effects, most notably weight gain.

Antidepressants may trigger a switch from depression to mania; therefore, they are usually used with a mood stabilizer.

Selected Drugs for Bipolar Disorder*

Drug

Indication

Starting Dose

Maintenance Dose

Comments

Lithium

Lithium extended-release ‡,§

Acute mania and maintenance

300 mg bid

300–1200 mg bid

Dose titrated to a blood level of 0.8–1.2 mEq/L

Antipsychotics

Aripiprazole §

Acute mania

Psychosis

2–5 mg once/day

Up to 30 mg once/day

Limited experience in children

Chlorpromazine ‡,§

Acute mania

Psychosis

10 mg once/day

50–300 mg bid

Rarely used because newer drugs have a more favorable adverse effect profile

Olanzapine §

Acute mania

Psychosis

2.5–5 mg once/day

Up to 10 mg bid

Causes weight gain, which may limit use in some patients

Paliperidone ‡,§

Acute mania

Psychosis

3 mg once/day

Up to 3 mg bid

Closely related to risperidone

Very limited experience in children

Risperidone §

Acute mania

Psychosis

0.5 mg once/day

Up to 2.5 mg/day in divided doses (eg, 0.5 mg tid)

Maintenance dose highly variable

In high doses, increased risk of neurologic adverse effects

Quetiapine §

Acute mania

Psychosis

25 mg bid

Up to 200 mg bid

Causes sedation that may limit dose increases

Olanzapine/fluoxetine fixed combination ‡,§

Bipolar depression

6 mg/25 mg once/day

Up to 12 mg/50 mg once/day

Limited experience in children

Ziprasidone §

Acute mania

Psychosis

20 mg bid

Up to 80 mg bid

Very limited experience in children

Anticonvulsants

Carbamazepine

Acute mania and mixed episode

200 mg bid

Up to 600 mg bid

Metabolic enzyme induction, possibly requiring dose adjustments

Divalproex

Acute mania

250 mg bid

Up to 30 mg/kg bid in divided doses

Dose titrated to a blood level of 50–125 μg/mL

Lamotrigine

Maintenance

25 mg once/day

Up to 100 mg bid

Requires that dosing guidelines in the package insert be followed closely

*These drugs pose a small but serious risk for a wide variety of major adverse effects. Therefore, benefits must be carefully weighed against potential risks.

Dose ranges are approximate. Interindividual variability in therapeutic response and adverse effects is considerable. This table is not a substitute for the full prescribing information.

These drugs have not been studied in children.

§ These drugs increase the risk of weight gain, negative effects on the lipid profile, increases in glucose and prolactin levels, and QT prolongation.

Resources In This Article

Drugs Mentioned In This Article

  • Drug Name
    Select Trade
  • LITHOBID
  • LEVOPHED
  • No US brand name
  • SEROQUEL
  • PROZAC, SARAFEM
  • ABILIFY
  • RISPERDAL
  • GEODON
  • LAMICTAL
  • ZYPREXA
  • INVEGA
  • TEGRETOL

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