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- Extracranial Head Injuries
- Facial Nerve Injury
- Brachial Plexus Injuries
- Phrenic Nerve Injuries
- Other Peripheral Nerve Injuries
- Spinal Cord Injury
- Intracranial Hemorrhage
- Soft-Tissue Injuries
The forces of labor and delivery occasionally cause physical injury to the infant. The incidence of neonatal injury from difficult or traumatic deliveries is decreasing due to increasing use of cesarean delivery in place of difficult versions, vacuum extractions, or mid- or high-forceps deliveries.
A traumatic delivery is more likely when the mother has small pelvic measurements, when the infant seems large for gestational age (often the case with diabetic mothers), or when there is a breech or other abnormal presentation, especially in a primipara. In such situations, labor and the fetal condition should be monitored closely. If fetal distress is detected, the mother should be positioned on her side and given O 2 . If fetal distress persists, an immediate cesarean delivery should be done.
Head injury is the most common birth-related injury and is usually minor, but serious injuries sometimes occur.
Subgaleal hemorrhage occurs between the galea aponeurosis and periosteum. It results from greater trauma and is characterized by a fluctuant mass over the entire scalp, including the temporal regions, and manifests in the first few hours after birth. This potential space under the scalp is large, and there can be significant blood loss and hemorrhagic shock. Treatment is mostly supportive.
Cephalhematoma is hemorrhage beneath the periosteum. It can be differentiated from subgaleal hemorrhage because it is sharply limited to the area overlying a single bone, the periosteum being adherent at the sutures. Cephalhematomas are commonly unilateral and parietal. In a small percentage of neonates, there is a linear fracture of the underlying bone. The hematoma usually presents in the first few days of life and resolves over weeks. Treatment is not required, but anemia or hyperbilirubinemia may result. Occasionally, the hematoma calcifies into a bony mass.
Depressed skull fractures are uncommon. Most result from an assisted delivery using forceps or from the head resting on a bony prominence in utero. Infants with depressed skull fractures or other head trauma may also have subdural bleeding, subarachnoid hemorrhage, or contusion or laceration of the brain itself (see Intracranial Hemorrhage). Depressed skull fractures cause a palpable (and sometimes visible) step-off deformity, which must be differentiated from the palpable elevated periosteal rim occurring with cephalhematomas. CT is done to confirm the diagnosis and rule out complications. Neurosurgical elevation may be needed.
The facial nerve is injured most often. Although forceps pressure is a common cause, some injuries probably result from pressure on the nerve in utero, which may be due to fetal positioning (eg, from the head lying against the shoulder, the sacral promontory, or a uterine fibroid).
Facial nerve injury usually occurs at or distal to its exit from the stylomastoid foramen and results in facial asymmetry, especially during crying. Identifying which side of the face is affected can be confusing, but the facial muscles on the side of the nerve injury cannot move. Injury can also occur to individual branches of the nerve, most often the mandibular.
Another cause of facial asymmetry is mandibular asymmetry resulting from intrauterine pressure; in this case, muscle innervation is intact and both sides of the face can move. In mandibular asymmetry, the maxillary and the mandibular occlusal surfaces are not parallel, which differentiates it from a facial nerve injury. A congenital anomaly that can cause an asymmetric smile is unilateral absence of the depressor anguli oris muscle; this anomaly is clinically insignificant but must be differentiated from facial nerve injury.
Testing or treatment is not needed for peripheral facial nerve injuries or mandibular asymmetry. They usually resolve by age 2 to 3 mo.
Brachial plexus injuries frequently follow lateral stretching of the neck during delivery caused by shoulder dystocia, breech extraction, or hyperabduction of the neck in cephalic presentations. Injuries can be due to simple stretching of the nerve, hemorrhage within a nerve, tearing of the nerve or root, or avulsion of the roots with accompanying cervical cord injury. Associated injuries (eg, fractures of the clavicle or humerus or subluxations of the shoulder or cervical spine) may occur. Intrauterine compression may also cause some cases.
Injuries may involve the
The site and type of nerve root injury determine the prognosis.
Erb palsy is the most common brachial plexus injury. It is an upper brachial plexus (C5 to C7) injury causing adduction and internal rotation of the shoulder with pronation of the forearm. Sometimes the biceps reflex is absent and the Moro reflex is asymmetric. Ipsilateral paralysis of the diaphragm due to phrenic nerve injury also is common (see Phrenic Nerve Injuries). Treatment is usually supportive with physical therapy and protective positioning, which includes protecting the shoulder from excessive motion by immobilizing the arm across the upper abdomen and preventing contractures by gently doing passive range-of-motion exercises to involved joints every day starting at 1 wk of age.
Klumpke palsy is rare and is a lower plexus injury that causes weakness or paralysis of the hand and wrist. The grasp reflex is usually absent, but the biceps reflex is present. Often, the sympathetic fibers of T1 are involved causing an ipsilateral Horner syndrome (miosis, ptosis, facial anhidrosis—see Horner Syndrome). Passive range-of-motion exercises are usually the only treatment needed.
Neither Erb palsy nor Klumpke palsy commonly causes demonstrable sensory loss, which suggests a tear or avulsion. These conditions usually improve rapidly, but deficits can persist. If a significant deficit persists > 3 mo, MRI is done to determine the extent of injury to the plexus, roots, and cervical cord. Surgical exploration and microsurgical repair of brachial plexus with nerve grafts have sometimes been helpful.
Involvement of the entire plexus is less common and results in a flaccid upper extremity with little or no movement, absent reflexes, and usually sensory loss. Ipsilateral Horner syndrome is present in the most severe cases. Ipsilateral pyramidal signs (eg, decreased movement, Babinski sign) indicate spinal cord trauma; an MRI should be done. The involved extremity’s subsequent growth may be impaired. The prognosis for recovery is poor. Management may include neurosurgical exploration. Passive range-of-motion exercises can prevent contractures.
Most phrenic nerve injuries (about 75%) are associated with brachial plexus injury. Injury is usually unilateral and caused by a traction injury of the head and neck.
Infants have respiratory distress and decreased breath sounds on the affected side. Treatment is supportive and typically requires continuous positive airway pressure or mechanical ventilation. About one third of infants recover spontaneously within the first month. Infants who do not recover may require surgical diaphragmatic plication.
Injuries to other peripheral nerves (eg, the radial, sciatic, obturator) are rare in neonates and are usually not related to labor and delivery. They are usually secondary to a local traumatic event (eg, an injection in or near the sciatic nerve). Treatment includes placing the muscles antagonistic to those paralyzed at rest until recovery. Neurosurgical exploration of the nerve is seldom indicated. In most peripheral nerve injuries, recovery is complete.
Spinal cord injury (see also Spinal Cord Injury in Children) is rare and involves variable degrees of cord disruption, often with hemorrhage. Complete disruption of the cord is very rare. Trauma usually occurs in breech deliveries after excess longitudinal traction to the spine. It can also be caused by cord compression due to epidural hemorrhage or hyperextension of the fetal neck in utero (the “flying fetus”). Injury usually affects the lower cervical region (C5 to C7). When the injury is higher, lesions are usually fatal because respiration is completely compromised. Sometimes a click or snap is heard at delivery.
Spinal shock with flaccidity below the level of injury occurs initially. Usually, there is patchy retention of sensation or movement below the lesion. Spasticity develops within days or weeks. Breathing is diaphragmatic because the phrenic nerve remains intact because its origin is higher (at C3 to C5) than the typical cord lesion. When the spinal cord lesion is complete, the intercostal and abdominal muscles become paralyzed and rectal and bladder sphincters cannot develop voluntary control. Sensation and sweating are lost below the involved level, which can cause fluctuations of body temperature with environmental changes.
An MRI of the cervical cord may show the lesion and excludes surgically treatable lesions, such as congenital tumors or hematomas pressing on the cord. The CSF is usually bloody.
With appropriate care, most infants survive for many years. The usual causes of death are recurring pneumonia and progressive loss of renal function. Treatment includes nursing care to prevent skin ulcerations, prompt treatment of urinary and respiratory infections, and regular evaluations to identify obstructive uropathy early.
Hemorrhage in or around the brain can occur in any neonate but is particularly common among those born prematurely; about 15 to 25% of premature infants < 1500 g have intracranial hemorrhage. Hypoxia-ischemia, variations in BP, hypoperfusion with reperfusion, and pressures exerted on the head during labor are major causes. The presence of the germinal matrix (a mass of embryonic cells lying over the caudate nucleus on the lateral wall of the lateral ventricles that is vulnerable to hemorrhage) makes hemorrhage more likely. Risk also is increased by hematologic disorders (eg, vitamin K deficiency, hemophilia, disseminated intravascular coagulation).
Hemorrhage can occur in several CNS spaces. Small hemorrhages in the subarachnoid space, falx, and tentorium are frequent incidental findings at autopsy of neonates that have died from non-CNS causes. Larger hemorrhages in the subarachnoid or subdural space, brain parenchyma, or ventricles are less common but more serious.
Intracranial hemorrhage is suspected in neonates with apnea, seizures, lethargy, or an abnormal neurologic examination. Such infants should have a cranial imaging study as part of the initial evaluation. Cranial ultrasonography is risk free, requires no sedation, and can readily identify blood within the ventricles or brain substance. CT is more sensitive than ultrasonography for thin layers of blood in the subarachnoid or subdural spaces and for bony injury. MRI is more sensitive and specific than CT or ultrasonography for intracranial blood and for brain injury. CT is done to rapidly identify intracranial hemorrhage.
Treatment depends on the location and severity of the hemorrhage but usually is only supportive, including giving vitamin K if not previously given and managing any underlying coagulation abnormality. In cases of significant hemorrhage (eg, subdural hemorrhage), neurosurgical consultation should be obtained to help identify infants requiring intervention.
Epidural hematoma is a collection of blood between the skull and the dura mater. It is rare in neonates but can occur in association with a skull fracture or cephalhematoma. Infants may present with apnea, seizures, or focal neurologic abnormalities. The fontanelles may be bulging if intracranial pressure is increased. Most epidural hematomas are self-limiting and do not require treatment. If an intervention is required, surgical and nonsurgical options exist. Nonsurgical options are percutaneous epidural tapping or ultrasound-guided needle aspiration. Surgical options include craniotomy, which is reserved for cases that are rapidly progressing or not responsive to other interventions. If identified and treated promptly, neurologic outcomes are good.
Intraventricular and/or intraparenchymal hemorrhage usually occurs during the first 3 days of life and is the most serious type of intracranial bleeding. Hemorrhages occur most often in premature infants, are often bilateral, and usually arise in the germinal matrix. Cases in term infants are rare. Most bleeding episodes are subependymal or intraventricular and involve a small amount of blood. In severe hemorrhage, there may be bleeding into the parenchyma or a cast of the ventricular system with large amounts of blood in the cisterna magna and basal cisterns. Hypoxia-ischemia often precedes intraventricular and subarachnoid bleeding. Hypoxia-ischemia damages the capillary endothelium, impairs cerebral vascular autoregulation, and can increase cerebral blood flow and venous pressure, all of which make hemorrhage more likely. Most intraventricular hemorrhages are asymptomatic, but larger hemorrhages may cause apnea, cyanosis, or sudden collapse.
Prognosis for infants with small intraventricular hemorrhages is good. However, infants with large intraventricular hemorrhages have a poor prognosis, especially if the hemorrhage extends into the parenchyma. Many infants who survive have residual neurologic deficits. Preterm infants with a history of severe intraventricular hemorrhage are at risk of developing posthemorrhagic hydrocephalus and must be monitored closely with serial cranial ultrasound examinations and frequent head circumference measurements.
Treatment for most hemorrhages is only supportive. However, infants with progressive hydrocephalus require CSF drainage by placement of a subcutaneous ventricular reservoir or one of the various types of ventricular shunts (eg, ventriculoperitoneal). Because many infants will have neurologic deficits, careful follow-up and referral for early intervention services are important.
Subarachnoid hemorrhage probably is the most common type of intracranial hemorrhage. It involves bleeding between the arachnoid membrane and the pia mater. Neonates typically present in the 2nd or 3rd day of life with apnea, seizures, lethargy, or an abnormal neurologic examination.
The prognosis is usually good, with no significant long-term sequelae. However, with large hemorrhages, the associated meningeal inflammation may lead to a communicating hydrocephalus as the infant grows.
Treatment is supportive.
Subdural hemorrhage involves bleeding between the dura and the pia mater. It results from tears in the falx, tentorium, or bridging veins. Such tears tend to occur in neonates of primiparas, in large neonates, or after difficult deliveries—conditions that can produce unusual pressures on intracranial vessels. Some subdural hemorrhages are nontraumatic. Infants may present with apnea, seizures, a rapidly enlarging head, an abnormal neurologic examination with hypotonia, a poor Moro reflex, or extensive retinal hemorrhages.
The prognosis for subdural hemorrhage is guarded, but some infants do well.
Treatment is supportive, but neurosurgical drainage of the hematoma is usually needed for rapidly progressing bleeding with compression of vital intracranial structures and worsening clinical signs.
Midclavicular fracture , the most common fracture during birth, occurs with shoulder dystocia and with normal, nontraumatic deliveries. Initially, the neonate is sometimes irritable and may not move the arm on the involved side either spontaneously or when the Moro reflex is elicited. Most clavicular fractures are greenstick and heal rapidly and uneventfully. A large callus forms at the fracture site within a week, and remodeling is completed within a month. Treatment consists of immobilizing the arm for 14 days by pinning the shirt sleeve of the involved side to the opposite side of the infant’s shirt.
The humerus and femur may be fractured in difficult deliveries. Most of these are greenstick, mid-shaft fractures, and excellent remodeling of the bone usually follows, even if moderate angulation occurs initially. A long bone may be fractured through its epiphysis, but prognosis is excellent.
All soft tissues are susceptible to injury during birth if they have been the presenting part or the fulcrum for the forces of uterine contraction. Edema and ecchymosis often follow injury, particularly of the periorbital and facial tissues in face presentations and of the scrotum or labia during breech deliveries. Breakdown of blood within the tissues and conversion of heme to bilirubin result whenever a hematoma develops. This added burden of bilirubin may cause sufficient neonatal hyperbilirubinemia to require phototherapy, and rarely, exchange transfusion (see Kernicterus). No other treatment is needed.
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