Peyronie's disease is fibrosis of the cavernous sheaths leading to contracture of the investing fascia of the corpora, resulting in a deviated and sometimes painful erection.
The disease occurs in adults. The cause is unknown but appears to be similar to that of Dupuytren's contracture. The contracture usually results in deviation of the erect penis to the involved side, occasionally causes painful erections, and may prevent penetration. Fibrosis may extend into the corpus cavernosum, compromising tumescence distally.
Resolution may occur spontaneously over many months. Mild Peyronie's disease that does not cause sexual dysfunction does not warrant treatment.
Treatment results are unpredictable. Oral vitamin E and K para-aminobenzoate have had varied success. Surgical removal of the fibrosis and replacement with a patch graft may be successful or may result in further scarring and exaggeration of the defect. A series of local injections of verapamil or high-potency corticosteroids into the plaque may be effective, but oral corticosteroids are not. Ultrasound treatments can stimulate blood flow, which may prevent further scarring. Radiation therapy may decrease pain; however, radiation often worsens tissue damage. To assist penetration, a prosthesis may be implanted but may require a patch procedure to straighten the penis.
Last full review/revision October 2008 by Paul D. Lui, MD