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Pronunciation
(DYE byoo kane)
Generic Available (U.S.)
Yes
Brand Names: U.S.
Pharmacologic Category
Pharmacologic Category Synonyms
Use: Labeled Indications
Fast, temporary relief of pain and itching due to hemorrhoids, minor burns
Use: Dental
Amide derivative local anesthetic for minor skin conditions
Breast-Feeding Considerations
No data reported; however, topical administration is probably compatible.
Contraindications
Hypersensitivity to amide-type anesthetics, ophthalmic use
Warnings/Precautions
Other warnings/precautions:
• Topical application: When topical anesthetics are used prior to cosmetic or medical procedures, the lowest amount of anesthetic necessary for pain relief should be applied. High systemic levels and toxic effects (eg, methhemoglobinemia, irregular heart beats, respiratory depression, seizures, death) have been reported in patients who (without supervision of a trained professional) have applied topical anesthetics in large amounts (or to large areas of the skin), left these products on for prolonged periods of time, or have used wraps/dressings to cover the skin following application.
Adverse Reactions
1% to 10%:
Dermatologic: Angioedema, contact dermatitis
Local: Burning
Metabolism/Transport Effects
None known.
Drug Interactions
There are no known significant interactions.
Storage
Darkens on light exposure.
Mechanism of Action
Local anesthetics bind selectively to the intracellular surface of sodium channels to block influx of sodium into the axon. As a result, depolarization necessary for action potential propagation and subsequent nerve function is prevented. The block at the sodium channel is reversible. When drug diffuses away from the axon, sodium channel function is restored and nerve propagation returns.
Pharmacodynamics/Kinetics
Onset of action: ~15 minutes
Duration: 2-4 hours
Absorption: Poor through intact skin; well absorbed through mucous membranes and excoriated skin
Dosage
Children and Adults: Topical: Apply gently to the affected areas; no more than 30 g for adults or 7.5 g for children should be used in any 24-hour period
Dental Usual Dosing
Local pain (local anesthetic): Children and Adults: Topical: Apply gently to the affected areas; no more than 30 g for adults or 7.5 g for children should be used in any 24-hour period
Dental Health: Effects on Dental Treatment
No significant effects or complications reported
Dental Health: Vasoconstrictor/Local Anesthetic Precautions
No information available to require special precautions
Mental Health: Effects on Mental Status
None reported
Mental Health: Effects on Psychiatric Treatment
None reported
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Ointment, topical: 1% [10 mg/g] (30 g)
Nupercainal®: 1% [10 mg/g] (30 g, 60 g) [contains sodium bisulfite]
Pricing: U.S. (www.drugstore.com)
Ointment (Dibucaine)
1% (30): $12.99
International Brand Names
Lexi-Comp.com
Last full review/revision January 2012
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