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Pronunciation
(e KONE a zole)
Generic Available (U.S.)
Yes
Index Terms
Pharmacologic Category
Pharmacologic Category Synonyms
Use: Labeled Indications
Topical treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), tinea corporis (ringworm), tinea versicolor, and cutaneous candidiasis
Pregnancy Risk Factor
C
Pregnancy Considerations
Fetotoxic and embryotoxic events were observed in animal reproduction studies following oral administration.
Lactation
Excretion in breast milk unknown/use caution
Contraindications
Hypersensitivity to econazole or any component of the formulation
Warnings/Precautions
Concerns related to adverse effects:
• Irritation: Discontinue if sensitivity or irritation occurs.
Other warnings/precautions:
• Appropriate use: For topical use only; avoid contact with eyes, mouth, nose, or other mucous membranes
Adverse Reactions
1% to 10%: Dermatologic: Burning (3%), erythema (3%), itching (3%), stinging (3%)
Postmarketing and/or case reports: Pruritic rash
Metabolism/Transport Effects
Inhibits CYP2E1 (weak)
Drug Interactions
There are no known significant interactions.
Storage
Store below 30°C (86°F).
Mechanism of Action
Alters fungal cell wall membrane permeability; may interfere with RNA and protein synthesis, and lipid metabolism
Pharmacodynamics/Kinetics
Absorption: <10%
Metabolism: Hepatic to more than 20 metabolites
Excretion: Urine (<1%); feces (<1%)
Dosage
Children and Adults: Topical:
Tinea pedis: Apply sufficient amount to cover affected areas once daily for 1 month
Tinea cruris, tinea corporis, tinea versicolor: Apply sufficient amount to cover affected areas once daily for 2 weeks
Cutaneous candidiasis: Apply sufficient quantity twice daily (morning and evening) for 2 weeks
Administration: Topical
Occasionally, longer treatment periods may be required. For external use only. Avoid contact with the eyes.
Monitoring Parameters
Reassess diagnosis if no clinical improvement after 2 weeks.
Patient Education
This medication is for external use only; avoid contact with eyes, mouth, nose, or other mucous membranes. Apply in sufficient quantity to cover affected area as often as directed by prescriber. Do not cover with occlusive dressings or wrapping unless otherwise directed. May cause temporary burning, itching, or stinging. Report if these persist, if condition worsen or persists, or if rash occurs.
Dental Health: Effects on Dental Treatment
No significant effects or complications reported
Dental Health: Vasoconstrictor/Local Anesthetic Precautions
No information available to require special precautions
Mental Health: Effects on Mental Status
None reported
Mental Health: Effects on Psychiatric Treatment
None reported
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Cream, topical, as nitrate: 1% (15 g, 30 g, 85 g)
Pricing: U.S. (www.drugstore.com)
Cream (Econazole Nitrate)
1% (15): $15.99
1% (30): $24.05
1% (85): $49.99
References
Heel RC, Brogden RN, Speight TM, et al, "Econazole: A Review of Its Antifungal Activity and Therapeutic Efficacy," Drugs, 1978, 16(3):177-201.
International Brand Names
Lexi-Comp.com
Last full review/revision January 2012
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