|
This information has been developed and provided by an independent third-party source. Merck & Co., Inc. does not endorse and is not responsible for the accuracy of the content, or for practices or
standards of non-Merck sources.
Pronunciation
(HYE droe kwin one)
Generic Available (U.S.)
Yes
Index Terms
Brand Names: U.S.
Brand Names: Canada
Pharmacologic Category
Use: Labeled Indications
Gradual bleaching of hyperpigmented skin conditions
Pregnancy Risk Factor
C
Lactation
Excretion in breast milk unknown/use caution
Contraindications
Hypersensitivity to hydroquinone or any component of the formulation; sunburn, depilatory usage
Warnings/Precautions
Other warnings/precautions:
• Appropriate use: Limit application to area no larger than face and neck or hands and arms.
Adverse Reactions
Frequency not defined.
Dermatologic: Dermatitis, dryness, erythema, stinging, inflammatory reaction, sensitization
Local: Irritation
Metabolism/Transport Effects
None known.
Drug Interactions
There are no known significant interactions.
Mechanism of Action
Produces reversible depigmentation of the skin by suppression of melanocyte metabolic processes, in particular the inhibition of the enzymatic oxidation of tyrosine to DOPA (3,4-dihydroxyphenylalanine); sun exposure reverses this effect and will cause repigmentation.
Pharmacodynamics/Kinetics
Onset and duration of depigmentation produced by hydroquinone varies among individuals
Dosage
Children >12 years and Adults: Topical: Apply thin layer and rub in twice daily
Administration: Topical
For external use only; avoid contact with eyes
Patient Education
Therapeutic effect may take several weeks. Test response by applying to small area of unbroken skin and check in 24 hours; if irritation or blistering occurs do not use. Avoid contact with eyes. Do not apply to open wounds or weeping areas. Before using, wash and dry area gently. Apply a thin film to affected area and rub in gently. Avoid direct sunlight or use sunblock or protective clothing to prevent repigmentation. Report rash, itching, or worsening of condition.
Dental Health: Effects on Dental Treatment
No significant effects or complications reported
Dental Health: Vasoconstrictor/Local Anesthetic Precautions
No information available to require special precautions
Mental Health: Effects on Mental Status
None reported
Mental Health: Effects on Psychiatric Treatment
None reported
Nursing: Physical Assessment/Monitoring
When applied to large areas or for extensive periods of time, monitor for skin irritation.
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Cream, topical: 4% (28.35 g, 28.4 g, 30 g); 5% (0.25 g [DSC])
Alphaquin HP®: 4% (28.4 g, 56.7 g) [contains sodium metabisulfite, sunscreen]
Eldopaque Forte®: 4% (28.35 g) [contains sodium metabisulfite, sunscreen]
Eldopaque®: 2% (28.35 g) [contains sodium metabisulfite, sunscreen]
Eldoquin Forte®: 4% (28.4 g) [contains sodium metabisulfite]
Eldoquin®: 2% (28.35 g) [contains sodium metabisulfite]
EpiQuin® Micro: 4% (40 g) [contains benzyl alcohol, sodium metabisulfite]
Esoterica® Daytime: 2% (85 g) [contains sodium metabisulfite]
Esoterica® Daytime: 2% (70 g) [contains sodium metabisulfite, sunscreen]
Esoterica® Nighttime: 2% (85 g) [contains sodium metabisulfite]
Lustra-AF®: 4% (56.8 g) [contains benzyl alcohol, ethanol, sodium metabisulfite, sunscreen]
Lustra-Ultra™: 4% (23.4 g [DSC], 56.8 g) [contains sodium metabisulfite, sunscreen]
Lustra®: 4% (56.8 g) [contains benzyl alcohol, sodium metabisulfite]
Melpaque HP®: 4% (14.2 g, 28.4 g) [contains sodium metabisulfite, sunblock]
Melquin HP®: 4% (14.2 g, 28.4 g) [contains sodium metabisulfite]
Nuquin HP®: 4% (14.2 g, 28.4 g, 56.7 g) [contains ethanol, sodium metabisulfite, sunscreen]
Palmer's® Skin Success® Eventone® Fade Cream: 2% (75 g, 81 g [DSC], 132 g [DSC]) [contains sodium sulfite, sunscreen; dry skin formula]
Palmer's® Skin Success® Eventone® Fade Cream: 2% (75 g, 81 g [DSC], 132 g [DSC]) [contains sodium sulfite, sunscreen; oily skin formula]
Palmer's® Skin Success® Eventone® Fade Cream: 2% (75 g, 125 g) [contains sodium sulfite, sunscreen; regular skin formula]
Emulsion, topical:
Aclaro PD®: 4% (42.5 g) [contains benzyl alcohol, sunscreen]
Aclaro®: 4% (48.2 g) [contains benzyl alcohol, sodium metabisulfite, sunscreen]
Gel, topical: 4% (28.35 g)
NeoStrata® HQ Skin Lightening: 2% (30 g) [contains ethanol, sodium bisulfite, sodium sulfite]
Nuquin HP®: 4% (14.2 g, 28.4 g) [contains ethanol, sodium metabisulfite, sunscreen]
Lotion, topical:
Palmer's® Skin Success® Eventone® Fade Milk: 2% (250 mL) [contains corn oil, sodium metabisulfite, sodium sulfite, sunscreen]
Solution, topical:
Melanex®: 3% (30 mL [DSC]) [contains ethanol, sodium metabisulfite]
Melquin-3®: 3% (29.57 mL) [contains ethanol 45%, isopropyl alcohol 4%]
Palmer's® Skin Success® Eventone® Ultra Fade Serum: 2% (30 mL) [contains corn oil, shea nut derivatives, sodium metabisulfite, sodium sulfite, sunscreen]
Pricing: U.S. (www.drugstore.com)
Cream (Alphaquin HP)
4-5-7.5% (28.4): $42.99
Cream (Eldopaque Forte)
4% (28.35): $61.99
Cream (Eldoquin Forte)
4% (28.35): $60.99
4% (30): $99.99
Cream (Hydroquinone-Sunscreens)
4% (28.4): $47.99
Cream (Lustra)
4% (56.8): $137.06
Cream (Lustra-AF)
4% (56.8): $146.99
Cream (Lustra-Ultra)
4% (56.8): $142.79
Cream (Melpaque HP)
4% (28.4): $33.99
Cream (Melquin HP)
4% (30): $39.99
Cream (Nuquin HP)
4% (30): $34.99
Emulsion (Aclaro PD)
4% (42.5): $137.64
Gel (Hydroquinone-Sunscreens)
4% (28.35): $39.99
Solution (Melquin 3)
3% (30): $17.99
International Brand Names
Lexi-Comp.com
Last full review/revision January 2012
|
