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Pronunciation

(NAF ti feen)

Generic Available (U.S.)

No

Index Terms

• Naftifine Hydrochloride

Brand Names: U.S.

• Naftin®

Pharmacologic Category

• Antifungal Agent, Topical

Pharmacologic Category Synonyms

• Topical Antifungal Agent

Use: Labeled Indications

Topical treatment of tinea cruris (jock itch), tinea corporis (ringworm), and tinea pedis (athlete's foot)

Pregnancy Risk Factor

B

Pregnancy Considerations

Teratogenic events were not observed in animal studies.

Lactation

Excretion in breast milk unknown/use caution

Contraindications

Hypersensitivity to naftifine or any component of the formulation

Warnings/Precautions

Concerns related to adverse effects:

• Irritation: Discontinue if sensitivity or irritation occurs

Other warnings/precautions:

• Appropriate use: For topical use only; avoid contact with eyes, nose, mouth, or mucous membranes.

Adverse Reactions

1% to 10%:

Dermatologic: Burning/stinging (5% to 6%), erythema (≤2%), pruritus (1% to 2%)

Local: Dryness (3%), irritation (2%)

<1%: Rash, skin tenderness

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Mechanism of Action

Synthetic, broad-spectrum antifungal agent in the allylamine class; appears to have both fungistatic and fungicidal activity. Exhibits antifungal activity by selectively inhibiting the enzyme squalene epoxidase in a dose-dependent manner which results in a reduced synthesis of ergosterol, the primary sterol within the fungal membrane.

Pharmacodynamics/Kinetics

Absorption: Systemic: Cream: 6%; Gel: ≤4%

Half-life elimination: 2-3 days

Excretion: Urine and feces (as unchanged drug and/or metabolites)

Dosage

Adults: Topical: Apply cream once daily and gel twice daily (morning and evening) for up to 4 weeks

Geriatric Considerations

No specific recommendations for use in the elderly.

Dental Health: Effects on Dental Treatment

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions

No information available to require special precautions

Mental Health: Effects on Mental Status

None reported

Mental Health: Effects on Psychiatric Treatment

None reported

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Cream, topical, as hydrochloride:

Naftin®: 1% (30 g, 60 g, 90 g) [contains benzyl alcohol]

Gel, topical, as hydrochloride:

Naftin®: 1% (40 g, 60 g, 90 g) [contains ethanol 52%]

Pricing: U.S. (www.drugstore.com)

Cream (Naftin)

1% (30): $300.00

1% (60): $301.00

1% (90): $280.39

Gel (Naftin)

1% (40): $297.32

1% (60): $296.84

1% (90): $269.99

International Brand Names

• A Mei (TW)
• Chizocin (TW)
• Exoderil (AE, AT, BG, BH, CR, CY, CZ, DE, EE, EG, GR, GT, HK, HN, ID, IL, IQ, IR, JO, KP, KW, LB, LY, MY, NI, OM, PA, PK, PL, QA, RU, SA, SV, SY, TR, TW, YE)
• Fetimin (HR)
• Micosona (ES)
• Suadian (IT)

Lexi-Comp.com

Last full review/revision February 2012