Disruptive actions are common among patients with dementia and are the primary reason for up to 50% of nursing home admissions. Disruptive actions include wandering, restlessness, yelling, throwing, hitting, refusing treatment, incessantly questioning, disrupting work of staff members, insomnia, and crying. Behavioral and psychologic symptoms of dementia have not been well characterized, and their treatment is poorly understood.
Deciding what actions constitute a behavioral symptom is highly subjective. Tolerability (what actions caregivers can tolerate) depends partly on the patient's living arrangements, particularly safety. For example, wandering may be tolerable if a patient lives in a safe environment (with locks and alarms on all doors and gates); however, if the patient lives in a nursing home or hospital, wandering may be intolerable because it disturbs other patients or interferes with the operation of the institution. Many behaviors (eg, wandering, repeatedly questioning, being uncooperative) are better tolerated during the day. Whether sundowning (exacerbation of disruptive behaviors at sundown or early evening) represents decreased tolerance by caregivers or true diurnal variation is unknown. In nursing homes, 12 to 14% of patients with dementia act disruptively more often during the evening than during the day.
Behavioral and psychologic symptoms may result from functional changes related to dementia:
Patients with dementia often adapt poorly to the regimentation of institutional living. Mealtimes, bedtimes, and toileting times are not individualized. For many elderly patients with dementia, behavioral and psychologic symptoms develop or worsen after they are moved to a more restrictive environment.
Physical problems (eg, pain, shortness of breath, urinary retention, constipation, physical abuse) can exacerbate behavioral and psychologic symptoms partly because patients may be unable to adequately communicate what the problem is. Physical problems can lead to delirium, and delirium superimposed on chronic dementia may worsen the behavioral symptom.
The best approach is to characterize and classify the behavior, rather than to label all such behaviors agitation, a term with too many meanings to be useful. The Cohen-Mansfield Agitation Inventory is commonly used; it classifies behaviors as follows:
Specific behaviors, precipitating events (eg, feeding, toileting, drug administration, visits), and time the behavior started and resolved should be recorded; this information helps identify changes in pattern or intensity of a behavior and makes planning a management strategy easier. If behavior changes, a physical examination should be done to exclude physical disorders and physical abuse, but environmental changes (eg, a different caregiver) should also be noted because they, rather than a patient-related factor, may be the reason.
Depression, common among patients with dementia, may affect behavior and must be identified. It may first manifest as an abrupt change in cognition, decreased appetite, deterioration in mood, a change in sleep pattern (often hypersomnolence), withdrawal, decreased activity level, crying spells, talk of death and dying, sudden development of irritability or psychosis, or other sudden changes in behavior. Often, depression is suspected first by family members.
Psychotic behavior must also be identified because management differs. Presence of delusions or hallucinations indicates psychosis. Delusions and hallucinations must be distinguished from disorientation, fearfulness, and misunderstanding, which are common among patients with dementia. Delusions without paranoia may be confused with disorientation, but delusions are usually fixed (eg, a nursing home is repeatedly called a prison), and disorientation varies (eg, a nursing home is called a prison, a restaurant, and a home). Hallucinations occur without external sensory stimuli; hallucinations should be distinguished from illusions, which involve misinterpreting external sensory stimuli (eg, cellular phones, pagers).
Management of behavioral and psychologic symptoms of dementia is controversial and has been inadequately studied. Supportive measures are preferred; however, drugs are commonly used.
The environment should be safe and flexible enough to accommodate behaviors that are not dangerous. Signs to help patients find their way and doors equipped with locks or alarms can help ensure the safety of patients who wander. Flexible sleeping hours and organization of beds can help patients with sleeping problems. Measures used to treat dementia generally also help minimize behavioral symptoms:
If an institution cannot provide an appropriate environment for a particular patient, transferring the patient to one that can may be preferable to drug treatment.
Learning how dementia leads to behavioral and psychologic symptoms and how to respond to disruptive behavior can help family members and other caregivers provide care for and cope with the patient better.
Learning how to manage stress, which may be considerable, is essential. Stressed caregivers should be referred to support services (eg, social workers, caregiver support groups, home health aides) and should be told how to obtain respite care if such care is available.
Family members who are caregivers should be monitored for depression, which occurs in nearly half of them. Depression in caregivers should be treated promptly.
Drugs that improve cognition may also help manage behavioral and psychologic symptoms in patients with dementia. However, drugs directed primarily at behavior are used only when other approaches are ineffective and when drugs are essential for safety. The need for continued treatment should be reassessed at least every month. Drugs should be selected to target the most intolerable behaviors. Antidepressants, preferably SSRIs, should be prescribed only for patients with signs of depression.
Antipsychotics are often used even though their efficacy has been shown only in psychotic patients (see Schizophrenia and Related Disorders: Treatment). Other patients are unlikely to benefit and likely to experience adverse effects, particularly extrapyramidal symptoms. Tardive dyskinesia or tardive dystonia may develop; these conditions often do not resolve when the dose is reduced or the drug is stopped.
Choice of antipsychotic depends on relative toxicity. Of conventional antipsychotics, haloperidol is relatively nonsedating and has less potent anticholinergic effects but is most likely to cause extrapyramidal symptoms; thioridazine and thiothixene are less likely to cause extrapyramidal symptoms but are more sedating and have more anticholinergic effects than haloperidol. Second-generation (atypical) antipsychotics (eg, aripiprazole, olanzapine, quetiapine, risperidone) are minimally anticholinergic and cause fewer extrapyramidal symptoms than conventional antipsychotics; however, these drugs, used for an extended period, may be associated with an increased risk of hyperglycemia and all-cause mortality. Also, they may increase risk of stroke in elderly patients who have dementia-related psychosis.
If antipsychotics are used, they should be given in a low dose (eg, olanzapine 2.5 to 15 mg po once/day; risperidone 0.5 to 3 mg po q 12 h; haloperidol 0.5 to 1.0 mg po, IV, or IM bid or as needed) and for a short time.
Anticonvulsants, particularly valproate, may be useful in controlling impulsive behavioral outbursts.
Sedatives (eg, a short-acting benzodiazepine such as lorazepam 0.5 mg po q 12 h as needed) are sometimes used in the short term to alleviate event-related anxiety, but such treatment is not recommended for the long term.
Last full review/revision April 2013 by Juebin Huang, MD, PhD