In dogs, the lesions reported as eosinophilic granulomas histologically resemble the eosinophilic granuloma of cats, with marked collagen degeneration surrounded by a granulomatous and eosinophilic infiltrate. These lesions may be seen as ulcerated or vegetative masses in the oral cavity or, less commonly, as plaques, nodules, or papules on the lips and other areas of the body. Any breed may be affected, but Siberian Huskies and Cavalier King Charles Spaniels may be at greater risk.

Most lesions respond to corticosteroids, and therapy is usually oral prednisone or prednisolone (0.5–2 mg/kg/day initially, tapering the dosage over 20–30 days). Lesions recur in some dogs, in which case low-dose, every-other-day corticosteroid therapy is indicated.

Last full review/revision July 2011 by Stephen D. White, DVM, DACVD