Inherited myopathy of Great Danes is a noninflammatory condition of young Great Danes. Affected dogs have been identified in England, Australia, and Canada. An autosomal recessive mode of inheritance is suspected. Clinical signs include exercise-induced tremors, weakness, and muscle wasting. CK activity is usually elevated, fibrillation potentials are detected in skeletal muscles, and histopathology reveals a central core myopathy. Treatment is supportive, at best.
Last full review/revision March 2012 by Joseph Harari, MS, DVM, DACVS