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Overview of Autoimmune Disorders of Connective Tissue


Alana M. Nevares

, MD, The University of Vermont Medical Center

Medically Reviewed Oct 2022
Topic Resources

In an autoimmune disorder Autoimmune Disorders An autoimmune disorder is a malfunction of the body's immune system that causes the body to attack its own tissues. What triggers an autoimmune disorder is not known. Symptoms vary depending... read more , antibodies or cells produced by the body attack the body’s own tissues. Many autoimmune disorders affect connective tissue and a variety of organs. Connective tissue is the structural tissue that gives strength to joints, tendons, ligaments, and blood vessels.

Autoimmune rheumatic disorders include

Autoimmune disorders can affect other tissues in the body beside connective tissue, and some people with autoimmune disorders of connective tissue have other kinds of autoimmune disorders, such as Hashimoto thyroiditis Hashimoto Thyroiditis Hashimoto thyroiditis is chronic, autoimmune inflammation of the thyroid gland. Hashimoto thyroiditis results when antibodies in the body attacks the cells of the thyroid gland—an autoimmune... read more (an autoimmune thyroid disorder that can lead to overactivity or underactivity of the thyroid gland).


In autoimmune disorders, inflammation and the immune response may result in connective tissue damage, not only in and around joints but also in other tissues, including vital organs, such as the kidneys and organs in the gastrointestinal tract. The sac that surrounds the heart (pericardium), the membrane that covers the lungs (pleura), and even the brain can be affected. The type and severity of symptoms depend on which organs are affected.


  • A doctor's evaluation

  • Laboratory tests

  • Sometimes established criteria

An autoimmune disorder of connective tissue (also called an autoimmune rheumatic disorder or autoimmune collagen-vascular disorder) is diagnosed on the basis of its particular symptom pattern, the findings during a physical examination, and the results of laboratory tests (such as blood tests and biopsies). For some of these disorders, doctors can also base the diagnosis on an established set of criteria.

Sometimes the symptoms of one disease overlap with those of another so much that doctors cannot make a distinction. In this case, the disorder may be called undifferentiated connective tissue disease or an overlap disease.


  • Corticosteroids and/or other drugs that suppress the immune system

Many autoimmune disorders of connective tissue are treated with corticosteroids, other drugs that suppress the immune system (immunosuppressive drugs), or both.

People who take corticosteroids, such as prednisone, are at risk of fractures related to osteoporosis Osteoporosis Osteoporosis is a condition in which a decrease in the density of bones weakens the bones, making breaks (fractures) likely. Aging, estrogen deficiency, low vitamin D or calcium intake, and... read more Osteoporosis . To prevent osteoporosis, these people may be given the drugs used to treat osteoporosis, such as bisphosphonates, denosumab, teriparatide, and supplemental vitamin D and calcium.

In people who have overlap diseases, doctors treat symptoms and organ dysfunction as they develop.

Although many people who have autoimmune disorders of connective tissue have tried changing their diet to reduce the inflammation caused by these disorders, as of now there are no compelling scientific data that an "anti-inflammatory" diet can alter the course of autoimmune disorders.

Drugs Mentioned In This Article

Generic Name Select Brand Names
Deltasone, Predone, RAYOS, Sterapred, Sterapred DS
Prolia, XGEVA
Calcidol, Calciferol, D3 Vitamin, DECARA, Deltalin, Dialyvite Vitamin D, Dialyvite Vitamin D3, Drisdol, D-Vita, Ergo D, Fiber with Vitamin D3 Gummies Gluten-Free, Happy Sunshine Vitamin D3, MAXIMUM D3, PureMark Naturals Vitamin D, Replesta, Replesta Children's, Super Happy SUNSHINE Vitamin D3, Thera-D 2000, Thera-D 4000, Thera-D Rapid Repletion, THERA-D SPORT, UpSpring Baby Vitamin D, UpSpring Baby Vitamin D3
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