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Joint Pain: Single Joint

(Monoarticular Joint Pain)

By

Alexandra Villa-Forte

, MD, MPH, Cleveland Clinic

Last full review/revision Feb 2021| Content last modified Feb 2021
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Pain that is isolated to just one joint is called monoarticular joint pain. A joint may simply be painful (arthralgia) or may also be inflamed (arthritis). Arthritis usually causes warmth, swelling, and rarely redness of the overlying skin. Pain may occur only when the joint is moved or also be present at rest. Fluid may collect within the joint (called an effusion).

Causes of Pain in a Single Joint

Common causes of arthritis in a single joint include infectious arthritis Infectious Arthritis Infectious arthritis is infection in the fluid and tissues of a joint usually caused by bacteria but occasionally by viruses or fungi. Bacteria, viruses, or fungi may spread through the bloodstream... read more , gout Gout and Calcium Pyrophosphate Arthritis read more and related disorders, and osteoarthritis Osteoarthritis (OA) Osteoarthritis is a chronic disorder that causes damage to the cartilage and surrounding tissues and is characterized by pain, stiffness, and loss of function. Arthritis due to damage of joint... read more Osteoarthritis (OA) . Joint pain may be the first symptom of a disorder that affects other organs in the body, such as an autoimmune disorder Overview of Autoimmune Disorders of Connective Tissue In an autoimmune disorder, antibodies or cells produced by the body attack the body’s own tissues. Many autoimmune disorders affect connective tissue and a variety of organs. Connective tissue... read more or a bodywide infection. Symptoms of some autoimmune disorders can include fever, mouth sores, and rash. Pain that develops in one joint may also be the first symptom of a disorder that eventually affects many joints (see also Joint Pain: Many Joints Joint Pain: Many Joints Pain that seems to be coming from joints can sometimes be coming from structures outside the joints, such as ligaments, tendons, or muscles (see Introduction to the Biology of the Musculoskeletal... read more ).

Common causes

At all ages, injury, infection, and crystals in the joint (often called crystal-induced arthritis) are the most common causes of sudden pain in a single joint.

Among young adults, the most common causes are

Among older adults who have not been injured, the most common causes are

The most dangerous cause at any age is acute infectious arthritis Infectious Arthritis Infectious arthritis is infection in the fluid and tissues of a joint usually caused by bacteria but occasionally by viruses or fungi. Bacteria, viruses, or fungi may spread through the bloodstream... read more . Infectious arthritis can damage structures inside the joint within hours, which can lead to permanent arthritis. Rapid treatment can minimize permanent damage and prevent sepsis and death.

Less common causes

Evaluation of Pain in a Single Joint

The following information can help people decide when a doctor’s evaluation is needed and help them know what to expect during the evaluation.

Warning signs

In people with pain in a single joint, certain symptoms and characteristics are cause for concern and are more likely to require immediate treatment. They include

  • Sudden or severe pain

  • Joint redness, warmth, swelling, or limitation of motion

  • Fever

  • Broken, red, warm, or tender skin near the joint

  • Presence of a bleeding disorder, use of anticoagulants ("blood thinners," for example, warfarin), or abnormal blood hemoglobin (for example, sickle cell disease)

  • Signs of sudden illness other than joint pain

  • Possibility of a sexually transmitted disease (for instance, due to unprotected sex with a new partner)

When to see a doctor

People with warning signs should see a doctor right away. Doctors are better able to treat symptoms more rapidly and completely if treatment occurs early in certain disorders, including crystal-induced arthritis, hemarthrosis, and infectious arthritis. People without warning signs, particularly if the cause of pain is known (for example, if typical pain recurs in a joint affected by osteoarthritis or if pain occurs after a minor injury) and symptoms are mild, can wait a few days and see whether symptoms resolve before seeing a doctor.

What the doctor does

Doctors first ask questions about the person's symptoms and medical history. Doctors then do a physical examination. What they find during the history and physical examination often suggests a cause of the pain and the tests that may need to be done (see table Some Causes and Features of Pain in a Single Joint Some Causes and Features of Pain in a Single Joint Pain that is isolated to just one joint is called monoarticular joint pain. A joint may simply be painful (arthralgia) or may also be inflamed (arthritis). Arthritis usually causes warmth, swelling... read more ).

During the history, doctors ask about the following:

  • When the pain started, how it has progressed, where it is located, and its severity

  • What makes the pain better or worse (for example, movement, weight-bearing exercise, or rest)

  • Previous injuries or previous joint pain

  • Symptoms in other joints (such as swelling)

  • Risk factors for sexually transmitted diseases and Lyme disease

  • Known disorders, particularly those that could cause or contribute to joint pain (such as osteoarthritis, gout, or sickle cell disease)

The physical examination focuses on the joints for signs of inflammation (including swelling, warmth, and rarely redness), tenderness, limitation of motion, and noises made when the joint moves (called crepitus Joint Noises Joint noises (crepitus), such as creaks and clicks, are common among many people without any joint disorders, but they can occur with specific problems of the joints. For example, the base of... read more ). Doctors compare the affected joint with the coordinating unaffected joint on the opposite side of the body to look for any subtle changes. Doctors also look for signs of infection elsewhere on the body, particularly on the skin and genitals.

Several findings from the history and examination give clues to the cause of joint pain:

  • Based on the examination, doctors can usually tell whether the source of the pain is the joint or nearby structures. For example, if only one side of a joint seems abnormal, the source of the pain is probably outside of the joint.

  • Based on the examination, doctors can usually tell whether fluid is in the joint.

  • Inflammation that develops over hours is usually caused by crystal-induced arthritis, particularly if similar symptoms have occurred previously. Infectious arthritis is another major cause of acute arthritis.

  • Fever is most often caused by infectious arthritis or crystal-induced arthritis.

Table
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Testing

The need for tests depends on what doctors find during the history and physical examination, particularly whether warning signs are present.

Possible tests include

  • Testing of joint fluid

  • X-rays and other imaging tests

  • Sometimes blood tests

Doctors usually test the fluid in the joint if the joint is swollen. Doctors extract the fluid from the joint by first sterilizing the area with an antiseptic solution and then numbing the skin with an anesthetic. Then a needle is inserted into the joint and joint fluid is withdrawn (a procedure called joint aspiration Joint aspiration (arthrocentesis) A doctor can often diagnose a musculoskeletal disorder based on the history and the results of a physical examination. Laboratory tests, imaging tests, or other diagnostic procedures are sometimes... read more Joint aspiration (arthrocentesis) or arthrocentesis). This procedure causes little or no pain. The fluid is usually tested for, among other things, bacteria that can cause infection and is examined under a microscope for crystals that cause gout and related disorders. Sometimes doctors do not test the fluid if the cause of the joint pain is obvious, for example, the pain occurs after an injury or fluid accumulates repeatedly in a joint with a chronic joint disorder such as osteoarthritis.

X-rays X-rays A doctor can often diagnose a musculoskeletal disorder based on the history and the results of a physical examination. Laboratory tests, imaging tests, or other diagnostic procedures are sometimes... read more X-rays may be taken, but they are usually unnecessary in people with acute arthritis. X-rays do not show abnormalities of soft tissues or cartilage. X-rays are most helpful in diagnosing fractures and sometimes bone tumors or osteonecrosis.

Magnetic resonance imaging Computed tomography (CT) and magnetic resonance imaging (MRI) A doctor can often diagnose a musculoskeletal disorder based on the history and the results of a physical examination. Laboratory tests, imaging tests, or other diagnostic procedures are sometimes... read more Computed tomography (CT) and magnetic resonance imaging (MRI) (MRI) or computed tomography Computed tomography (CT) and magnetic resonance imaging (MRI) A doctor can often diagnose a musculoskeletal disorder based on the history and the results of a physical examination. Laboratory tests, imaging tests, or other diagnostic procedures are sometimes... read more Computed tomography (CT) and magnetic resonance imaging (MRI) (CT) can show abnormalities of bones, joints, tendons, and muscles in more detail than x-rays. Thus, MRI or CT is used to diagnose bone and joint abnormalities that may not be evident or clear on x-rays (for example, hip fractures that are too small to be seen on x-rays). MRI is used to diagnose certain soft-tissue abnormalities, such as rotator cuff abnormalities in the shoulder and ligament and meniscus cartilage abnormalities in the knee.

Treatment of Pain in a Single Joint

The most effective way to relieve joint pain is to treat the disorder causing the pain. For example, antibiotics can be given to treat infectious arthritis. Bones with fractures may need to be immobilized (for example, set in a cast).

Immobilizing a joint with a splint or sling is sometimes a useful temporary way to relieve pain. Applying cold Cold therapy (cryotherapy) Professional rehabilitation therapists treat pain and inflammation. Such treatment makes movement easier and enables people to participate more fully in rehabilitation. Techniques used include... read more (for example, with ice) is the best treatment immediately after an injury has occurred and can be used for relieving pain caused by joint inflammation. Applying heat Heat therapy Professional rehabilitation therapists treat pain and inflammation. Such treatment makes movement easier and enables people to participate more fully in rehabilitation. Techniques used include... read more (for example, with a heating pad) may decrease pain by relieving spasms in the muscles around joints. However, people should protect their skin from extremes of heat and cold. For example, ice should be put in a rubber ice bag or a plastic bag wrapped in a towel and not applied to the skin directly. Also, hot and cold materials should be applied for at least 15 minutes at a time to penetrate deeply enough to affect the most painful or inflamed tissues.

Key Points about Pain in a Single Joint

  • Single-joint pain in older adults is most often caused by osteoarthritis or gout.

  • Single-joint pain in young adults or adolescents may be caused by a sexually transmitted disease such as gonorrhea.

  • People who have sudden joint pain with swelling should be evaluated by a doctor as soon as possible so that infectious arthritis, if present, can be promptly treated.

  • Fluid from swollen joints is usually withdrawn and tested for infection and the presence of crystals.

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