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Arthrogryposis Multiplex Congenita


Simeon A. Boyadjiev Boyd

, MD, University of California, Davis

Last full review/revision May 2020| Content last modified May 2020
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Arthrogryposis multiplex congenita refers to a variety of conditions that involve limited joint movement.

Any condition that impairs the movement of the baby while in the womb can result in arthrogryposis multiplex congenita. Such causes may involve


In infants with arthrogryposis multiplex congenita, a number of joints become curved and "frozen" and consequently cannot bend. Many infants have weakened muscles. Decreased movement of the baby's muscles and joints while in the womb likely cause the decreased movement of the joints after birth. Sometimes the nerves that would normally move the bones in the affected joints are also impaired. Infants with arthrogryposis may also have dislocated hips, knees, or elbows.


  • A doctor's evaluation

  • Genetic testing

After birth, doctors do a physical examination and note the baby's frozen joints and limbs. Doctors then do genetic testing by analyzing a sample of the baby's blood to look for chromosome and gene abnormalities. This testing can help doctors determine whether a specific disorder is the cause and rule out other causes.

Tests of the muscles, such as a muscle biopsy (removal of a sample of muscle for examination) and electromyography Electromyography and Nerve Conduction Studies Diagnostic procedures may be needed to confirm a diagnosis suggested by the medical history and neurologic examination. Electroencephalography (EEG) is a simple, painless procedure in which... read more Electromyography and Nerve Conduction Studies (EMG), may be done to help doctors distinguish between various types of arthrogryposis.


Babies born with arthrogryposis typically develop relatively normal intelligence, except when the arthrogryposis is caused by a disorder or syndrome that also affects intelligence. Doctors seek to establish a specific diagnosis for what has caused the arthrogryposis so that parents know what the prognosis is and can receive genetic counseling.


  • Casts and physical therapy

  • Sometimes surgery

Surgery may be needed to free the bones from attached tissue in order to have more normal joint movement. Surgically moving a muscle (for example, moving the triceps muscle so that it can flex rather than extend the elbow) may improve function.

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