Merck Manual

Please confirm that you are not located inside the Russian Federation

honeypot link

Ear Disorders Caused by Drugs



Lawrence R. Lustig

, MD, Columbia University Medical Center and New York Presbyterian Hospital

Last full review/revision Jun 2021| Content last modified Jun 2021
Click here for the Professional Version

Many drugs can damage the ears (ototoxic drugs). Some ototoxic drugs include the antibiotics streptomycin, tobramycin, gentamicin, neomycin, and vancomycin, certain chemotherapy drugs (for example, cisplatin), furosemide, and aspirin.

Whether people develop drug ototoxicity depends on many factors, including:

  • How much of the drug the person took (the dose)

  • How long the person took the drug

  • Whether the person has decreased kidney function, making it harder to clear the drug from a person's body

  • Whether the person has a family history of ear disorders caused by drugs

  • Whether the person's genetic make-up makes them more susceptible to the effects of ototoxic drugs

  • Whether the person is taking more than one ototoxic drug at the same time

Symptoms of Drug-Related Ear Disorders

Prevention of Drug-Related Ear Disorders

People should take the lowest effective dosage of ototoxic drugs, and the dosage should be closely monitored (for example, by measuring drug levels in the bloodstream when possible). If possible before beginning treatment with an ototoxic drug, people should have their hearing measured and then monitored during treatment, because symptoms are late warning signs that the drug has caused damage.

To prevent harming the fetus, pregnant women should avoid taking ototoxic antibiotics.

Older people and people with preexisting hearing loss should not be treated with ototoxic drugs if other effective drugs are available.

Treatment of Drug-Related Ear Disorders

When doctors detect ototoxicity they stop giving the drug (unless the disorder being treated is life-threatening and there are no other alternatives). There is no treatment to reverse ototoxicity, but sometimes hearing or loss of balance may partially recover on its own.

Drugs Mentioned In This Article

Generic Name Select Brand Names
No US brand name
NOTE: This is the Consumer Version. DOCTORS: Click here for the Professional Version
Click here for the Professional Version
Others also read

Test your knowledge

Otitis Media (Acute)
Acute otitis media is a bacterial or viral infection of the middle ear that often occurs as a complication of allergies or the common cold. While acute otitis media can occur at any age, it is most common among which of the following age groups?
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID

Also of Interest

Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID