Pseudohypoaldosteronism Type I
(See also Introduction to Disorders of Kidney Tubules.)
There are two types of pseudohypoaldosteronism:
Two different gene mutations can cause pseudohypoaldosteronism type I. In both, the body does not respond to the hormone aldosterone, leading to the excretion of too much sodium and water. However, the two types differ. In one type excess sodium is excreted only by the kidneys. In the other, more severe form, excess salt is also lost through sweat and from other organs.
Children with the severe form may have symptoms similar to those of cystic fibrosis, such as frequent respiratory tract infections. They may have
Sodium loss through sweat may cause a rash of very small red bumps.
The less severe form may cause few symptoms other than those of low blood pressure. In the less severe form, the disorder may resolve as children age.
In addition to measuring blood pressure, doctors measure the amount of sodium and potassium in the urine and blood. They may also do blood tests to detect levels of hormones that help regulate sodium levels in the blood and thus blood pressure (renin and aldosterone).
Genetic testing may also be done.
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