Merck Manual

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Non–X-Linked (Autosomal) Recessive Disorders
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Non–X-Linked (Autosomal) Recessive Disorders

    Some disorders represent a non–X-linked recessive trait. To have the disorder, a person usually must receive two abnormal genes, one from each parent. If both parents carry one abnormal gene and one normal gene, neither parent has the disorder but each has a 50% chance of passing the abnormal gene to the children. Therefore, each child has

    Therefore, among the children, the chance of not developing the disorder (that is, being normal or a carrier) is 75%.