Merck Manual

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Drugs for Serious Fungal Infections

Drugs for Serious Fungal Infections

Drug

Common Uses

Some Side Effects

Amphotericin B

Most fungal infections

Chills, fever, headache, vomiting, a low potassium level* in the blood, kidney failure, and anemia

Anidulafungin

Caspofungin

Micafungin

Nausea, diarrhea, headache, liver inflammation, inflammation of the vein, and rash

Fluconazole

Candidal and other fungal infections, including coccidioidomycosis and cryptococcal infections

Nausea, rash, and liver inflammation

Flucytosine

Candidal and cryptococcal infections

Nausea, vomiting, and bone marrow damage

Isavuconazole

Nausea, vomiting, and liver inflammation

Itraconazole

Nausea, diarrhea, liver inflammation, rash, headache, dizziness, a low potassium level* in the blood, high blood pressure, accumulation of fluid (edema), and heart failure

SUBA-itraconazole

Nausea, diarrhea, liver inflammation, rash, headache, dizziness, a low potassium level* in the blood, high blood pressure, accumulation of fluid (edema), and heart failure

Posaconazole

Aspergillus, candidal, and many other fungal infections

Nausea, vomiting, rash, and liver inflammation

Voriconazole

Aspergillus and candidal infections, fusariosis, and scedosporiosis

Temporary disturbances in vision (such as blurred vision, changes in color vision, and sensitivity to light), nausea, vomiting, rash, and liver inflammation

* A low potassium level (hypokalemia) can cause muscle weakness, cramping, and twitches and abnormal heart rhythms.

Flucytosine is usually used with other drugs.