Merck Manual

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Some Drugs That Can Cause Serotonin Syndrome

Some Drugs That Can Cause Serotonin Syndrome

Class

Drugs

Antidepressants: Monoamine oxidase inhibitors

Phenelzine

Selegiline

Tranylcypromine

Bupropion

Nefazodone

Trazodone

Venlafaxine

Citalopram

Escitalopram

Fluoxetine

Paroxetine

Sertraline

Antidepressants: Tricyclic antidepressants

Amitriptyline

Desipramine

Doxepin

Imipramine

Nortriptyline

Trimipramine

Central nervous system (CNS) stimulants

Methamphetamine

Methylphenidate

Phentermine

Sibutramine

Hallucinogens

Lysergic acid diethylamide (LSD)

5-Methoxy-diisopropyltryptamine ("Foxy Methoxy")

Herbs

Nutmeg

Syrian rue

5-Hydroxytryptamine (5-HT1) agonists (triptans)

Almotriptan

Eletriptan

Frovatriptan

Naratriptan

Rizatriptan

Sumatriptan

Zolmitriptan

Buprenorphine

Fentanyl

Hydrocodone

Meperidine

Oxycodone

Pentazocine

Tramadol

Others

Buspirone

Chlorpheniramine

Dextromethorphan

Granisetron

5-Hydroxytryptophan

Levodopa

Lithium

Metoclopramide

Olanzapine

Ondansetron

Risperidone

Ritonavir

Tryptophan

Valproate