Some Serious Adverse Drug Reactions
Adverse Drug Reaction |
Types of Drugs |
Examples |
|
Anemia (resulting from decreased production or increased destruction of red blood cells) |
Certain antibiotics |
Chloramphenicol |
|
Drugs used to treat malaria or tuberculosis in people with G6PD enzyme deficiency |
Chloroquine Isoniazid Primaquine |
|
|
Angioedema (swelling of the lips, tongue, and throat causing difficulty breathing) |
ACE inhibitors |
Captopril Enalapril Lisinopril |
|
Proton pump inhibitors |
Esomeprazole Lansoprazole Omeprazole |
|
|
Birth control drugs (all forms including patches and pills) |
Drospirenone/ethinyl estradiol Norelgestromin/ethinyl estradiol |
|
|
Confusion and drowsiness |
Sedatives, including many antihistamines |
Diphenhydramine |
|
Antidepressants (especially in older people) |
Amitriptyline Imipramine |
|
|
Decreased production of white blood cells, with increased risk of infection |
Certain antipsychotic drugs |
Clozapine |
|
Chemotherapy drugs |
Cyclophosphamide Mercaptopurine Methotrexate Vinblastine |
|
|
Some drugs used to treat thyroid disorders |
Propylthiouracil |
|
|
NSAIDs (repeated use of excessive doses) |
Ibuprofen Naproxen |
|
|
Aminoglycoside antibiotics |
Gentamicin Tobramycin |
|
|
Some chemotherapy drugs |
Cisplatin Methotrexate |
|
|
Antifungals |
Amphotericin B |
|
|
Some antibiotics |
Gentamicin Tetracycline (outdated) |
|
|
Some analgesics |
Acetaminophen (use of excessive doses) |
|
|
Some drugs used to treat tuberculosis |
Isoniazid |
|
|
Iron supplements (in excessive amounts) |
— |
|
|
Antidepressants |
Duloxetine |
|
|
Antibiotics |
Tetracycline |
|
|
Muscle tissue destruction (rhabdomyolysis) |
Statins |
Atorvastatin Simvastatin |
|
Stomach or intestinal ulcers (with or without bleeding) |
NSAIDs |
Aspirin Ibuprofen Naproxen |
|
Anticoagulants |
Heparin Warfarin |
|
|
Bisphosphonates |
Alendronate Risedronate |
|
|
Some antibiotics |
Penicillins Quinolones |
|
|
Anticonvulsants |
Phenytoin Valproic acid |
|
|
Antiarrhythmics |
Amiodarone Procainamide Sotalol |
|
|
Antipsychotics |
Chlorpromazine Haloperidol Lithium |
|
|
ACE = angiotensin-converting enzyme; G6PD = glucose-6-phosphate dehydrogenase; NSAIDs = nonsteroidal anti-inflammatory drugs. |
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