Table: Some Drugs That Cause Vitamin Deficiency - Merck Manuals Consumer Version

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Some Drugs That Cause Vitamin Deficiency

Drug	Vitamin
Alcohol	Folate Thiamin Vitamin B6
Antacids	Vitamin B12
Antibiotics, such as isoniazid, tetracycline, and trimethoprim-sulfamethoxazole	B vitamins Folate Vitamin K
Anticoagulants, such as warfarin	Vitamin E Vitamin K
Antiseizure drugs, such as phenytoin and phenobarbital	Biotin Folate Vitamin B6 Vitamin D Vitamin K
Antipsychotic drugs	Riboflavin Vitamin D
Barbiturates such as phenobarbital	Folate Riboflavin Vitamin D
Chemotherapy drugs, such as methotrexate	Folate
Cholestyramine	Vitamin A Vitamin D Vitamin E Vitamin K
Corticosteroids	Vitamin C Vitamin D
Cycloserine	Vitamin B6
Hydralazine	Vitamin B6
Levodopa	Vitamin B6
Mineral oil (long-term use)	Vitamin A Vitamin D Vitamin E Vitamin K
Metformin	Folate Vitamin B12
Nitrous oxide (repeated exposure)	Vitamin B12
Oral contraceptives	Folate Thiamin Vitamin B6
Penicillamine	Vitamin B6
Phenothiazines	Riboflavin
Primidone	Folate Vitamin D
Rifampin	Vitamin D Vitamin K
Sulfasalazine	Folate
Thiazide diuretics	Riboflavin
Triamterene	Folate
Tricyclic antidepressants, such as amitriptyline and imipramine	Riboflavin

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