Merck Manual

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Some Drugs That Cause Vitamin Deficiency

Some Drugs That Cause Vitamin Deficiency

Drug

Vitamin

Alcohol

Folate

Thiamin

Vitamin B6

Antacids

Vitamin B12

Antibiotics, such as isoniazid, tetracycline, and trimethoprim-sulfamethoxazole

B vitamins

Folate

Vitamin K

Anticoagulants, such as warfarin

Vitamin E

Vitamin K

Antiseizure drugs, such as phenytoin and phenobarbital

Biotin

Folate

Vitamin B6

Vitamin D

Vitamin K

Antipsychotic drugs

Riboflavin

Vitamin D

Barbiturates such as phenobarbital

Folate

Riboflavin

Vitamin D

Chemotherapy drugs, such as methotrexate

Folate

Cholestyramine

Vitamin A

Vitamin D

Vitamin E

Vitamin K

Corticosteroids

Vitamin C

Vitamin D

Cycloserine

Vitamin B6

Hydralazine

Vitamin B6

Levodopa

Vitamin B6

Mineral oil (long-term use)

Vitamin A

Vitamin D

Vitamin E

Vitamin K

Metformin

Folate

Vitamin B12

Nitrous oxide (repeated exposure)

Vitamin B12

Oral contraceptives

Folate

Thiamin

Vitamin B6

Penicillamine

Vitamin B6

Phenothiazines

Riboflavin

Primidone

Folate

Vitamin D

Rifampin

Vitamin D

Vitamin K

Sulfasalazine

Folate

Thiazide diuretics

Riboflavin

Triamterene

Folate

Tricyclic antidepressants, such as amitriptyline and imipramine

Riboflavin