Some Disorders and Symptoms That Can Be Worsened by Drugs in Older People

Disorder or Symptom

Drugs

Chronic kidney disease

Delirium, dementia, or mild cognitive impairment

Antipsychotic drugs

Corticosteroids

Fainting or orthostatic hypotension (sudden decrease in blood pressure when a person stands up)

Falls

Heart failure

Parkinson disease

Peptic ulcer disease or stomach bleeding

Urinary incontinence in women

Urinary retention or urinary symptoms caused by an enlarged prostate (such as slow urinary flow, frequent urination of smaller amounts, and dribbling)

Drugs with anticholinergic effects*, cold remedies containing decongestants, or a combination of antihistamines and decongestants

* Anticholinergic effects include confusion, blurred vision, constipation, dry mouth, light-headedness and loss of balance, and difficulty starting to urinate.

COX-2 inhibitors = coxibs; NSAIDs = nonsteroidal anti-inflammatory drugs.

Adapted from The American Geriatrics Society 2019 Beers Criteria Update Expert Panel: American Geriatrics Society updated Beers Criteria® for potentially inappropriate medication use in older adults. J Am Geriatr Soc 67(4):674-694, 2019. doi:10.1111/jgs.15767