Merck Manual

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Some Commonly Used Drugs That Can Cause Erectile Dysfunction

Some Commonly Used Drugs That Can Cause Erectile Dysfunction

Class

Drugs

Drugs to treat high blood pressure (antihypertensives)

Beta-blockers (such as atenolol, carvedilol, metoprolol, and propranolol)

Clonidine

Diuretics (such as furosemide, hydrochlorothiazide, and chlorthalidone)

Methyldopa

Spironolactone

Drugs to treat prostate enlargement

Alpha-adrenergic blockers (such as terazosin, doxazosin, tamsulosin, and silodosin)

5-Alpha-reductase inhibitors (such as finasteride and dutasteride)

Drugs to treat prostate cancer

Hormonal drugs (such as leuprolide, triptorelin, and goserelin)

Abiraterone

Bicalutamide

Ketoconazole

Drugs that affect the central nervous system

Alcohol

Benzodiazepines (such as alprazolam, chlordiazepoxide, diazepam, and lorazepam)

Cocaine or amphetamines, with chronic use

Monoamine oxidase inhibitors (such as phenelzine, selegiline, and tranylcypromine)

Opioids (such as codeine, heroin, hydromorphone, methadone, morphine, or oxycodone), if used chronically

Selective serotonin reuptake inhibitors (such as citalopram, escitalopram, fluoxetine, paroxetine, and sertraline)

Tricyclic antidepressants (such as amitriptyline, desipramine, imipramine, and nortriptyline)

Other

Androgen antagonists (such as megestrol)

Anticancer drugs (most cancer chemotherapy drugs)

Cimetidine

Drugs with anticholinergic effects (such as many antihistamines and some antidepressants)

Estrogens