Coenzyme Q10 (ubiquinone) is an enzyme that is naturally produced in the body. It participates in the energy-managing processes of cells and has an antioxidant effect. Antioxidants protect cells against damage by free radicals, which are highly chemically active by-products of normal cell activity. The levels of coenzyme Q10 seem to be lower in older people and in people with chronic diseases, such as heart problems, cancer, Parkinson disease, diabetes, human immunodeficiency virus (HIV) infection or AIDS, and muscular dystrophies. However, it is not known whether these low levels contribute to these disorders.
Rich dietary sources of coenzyme Q10 are meat, fish, and vegetable oils.
(See also Overview of Dietary Supplements Overview of Dietary Supplements Integrative medicine and health (IMH) and complementary and alternative medicine (CAM) include healing approaches and therapies that historically have not been included in conventional, mainstream... read more .)
Medicinal claims
Coenzyme Q10 is being studied for use in people with heart failure Heart Failure (HF) Heart failure is a disorder in which the heart is unable to keep up with the demands of the body, leading to reduced blood flow, back-up (congestion) of blood in the veins and lungs, and/or... read more 
, diabetes Diabetes Mellitus (DM) Diabetes mellitus is a disorder in which the body does not produce enough or respond normally to insulin, causing blood sugar (glucose) levels to be abnormally high. Urination and thirst are... read more , and degenerative neurologic disorders, such as Parkinson disease Parkinson Disease (PD) Parkinson disease is a slowly progressive degenerative disorder of specific areas of the brain. It is characterized by tremor when muscles are at rest (resting tremor), increased muscle tone... read more . Coenzyme Q10 may also help protect the heart from the toxic effects of certain cancer chemotherapy drugs (such as doxorubicin and daunorubicin). Although some preliminary studies suggest coenzyme Q10 may possess protective properties, more testing is needed. Coenzyme Q10 has also been studied as a drug to help relieve muscle pain, weakness, cramps, and soreness, but its effectiveness is not clear.
Possible side effects
Side effects are uncommon, but some people have digestive symptoms, such as abdominal pain, nausea, heartburn, diarrhea, and vomiting, and central nervous system symptoms, such as dizziness, light sensitivity, irritability, and headache. Other side effects include skin itching, rash, loss of appetite, fatigue, and flu-like symptoms.
Possible drug interactions
More Information about Coenzyme Q10
The following is an English-language resource that may be useful. Please note that THE MANUAL is not responsible for the content of this resource.
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National Institutes of Health (NIH), National Center for Complementary and Integrative Health: General information on the use of CoQ10 as a dietary supplement
Drugs Mentioned In This Article
| Generic Name | Select Brand Names |
|---|---|
warfarin |
COUMADIN |
