Nitrous oxide (laughing gas) is used as an anesthetic. It is also used as a propellant in cans and dispensers of whipped cream. Nitrous oxide is sometimes abused because it produces a sense of euphoria and a pleasant dreamlike state. Prolonged exposure to nitrous oxide can cause vitamin B12 deficiency Vitamin B12 Deficiency Vitamin B12 deficiency can occur in vegans who do not take supplements or as a result of an absorption disorder. Anemia develops, causing paleness, weakness, fatigue, and, if severe, shortness... read more , which leads to numbness and weakness in the legs and arms, which can be permanent. Nitrous oxide–filled balloons are illicitly sold and used at rock concerts and athletic events.
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National Institute on Drug Abuse (NIDA): Federal agency that supports scientific research into drug use and its consequences and supplies information about commonly used drugs, research priorities and progress, clinical resources, and grant and funding opportunities.
Substance Abuse and Mental Health Services Administration (SAMHSA): US Department of Health agency that leads public health efforts to improve behavioral health and provides resources, including treatment locators, toll-free helplines, practitioner training tools, statistics, and publications on a variety of substance-related topics.