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Hematopoietic Cell Transplantation


Robert Peter Gale

, MD, PhD, DSC(hc), Imperial College London

Last review/revision Aug 2022 | Modified Sep 2022
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Hematopoietic cell transplants Hematopoietic Stem Cell Transplantation Hematopoietic stem cell (HSC) transplantation is a rapidly evolving technique that offers a potential cure for hematologic cancers ( leukemias, lymphomas, myeloma) and other hematologic disorders... read more using cells from bone marrow, blood, or less often, umbilical cord blood cells are given after high- or moderate-dose chemotherapy and/or radiation therapy. Donors can be the person with cancer (an autotransplant) or a human leukocyte antigen (HLA)–matched related or unrelated person (an allotransplant—see also Overview of Cancer Therapy Overview of Cancer Therapy Curing cancer requires eliminating all cells capable of causing cancer recurrence in a person's lifetime. The major modalities of therapy are Surgery (for local and local-regional disease) Radiation... read more ). Typically, such transplants are reserved for patients with a high risk that conventional therapies will fail or in whom initial therapy has failed.

General reference

  • 1. Kanate AS, Majhail NS, Savani BN, et al: Indications for hematopoietic cell transplantation and immune effector cell therapy: Guidelines from the American Society for Transplantation and Cellular Therapy. Biol Blood Marrow Transplant 26(7):1247–1256, 2020. doi: 10.1016/j.bbmt.2020.03.002

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