antibiotic that is primarily bacteriostatic. It binds to the 50S subunit of the ribosome, thereby inhibiting bacterial protein synthesis.
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Pharmacokinetics
Gram-positive and gram-negative cocci and bacilli (including anaerobes)
Rickettsia, Mycoplasma, Chlamydia, and Chlamydophila species
Serious infections due to a few multidrug-resistant bacteria that remain susceptible to this antibiotic
Plague meningitis or endophthalmitis because other plague drugs penetrate these spaces poorly
Use During Pregnancy and Breastfeeding
Bone marrow depression (most serious)
Nausea, vomiting, and diarrhea
Gray baby syndrome (in neonates)
There are 2 types of bone marrow depression:
Reversible dose-related interference with iron metabolism: This effect is most likely with high doses or prolonged treatment or in patients with a severe liver disorder.
Irreversible idiosyncratic aplastic anemia: This anemia occurs in <
Hypersensitivity reactions are uncommon. Optic and peripheral neuritis may occur with prolonged use.
≤ 1 month of age > 25 mg/kg/day initially, and doses should be adjusted based on blood levels of the drug.