lincosamide antibiotic that is primarily bacteriostatic. It binds to the 50S subunit of the ribosome, thus inhibiting bacterial protein synthesis.
Pharmacokinetics
Some Clinical Uses of Macrolides) except
Effective for infections due to anaerobes (particularly Bacteroides species, including Bacteroides fragilis), community-acquired methicillin-resistant Staphylococcus aureusStreptococcus pneumoniae
Not reliably active against mycoplasmas, chlamydiae, Chlamydophila species, and legionellae
Aerobic gram-negative bacilli and enterococci are resistant.
Staphylococcus aureus
acne.
Use During Pregnancy and Breastfeeding
Clostridioides (formerly Clostridium) difficile–associated diarrhea (pseudomembranous colitis)
C. difficile colitis than any other antibiotic and has a black box warning for this adverse effect. C. difficileC. difficile compared to no antibiotics.
Hypersensitivity reactions may occur. The most commonly reported adverse effect is mild to moderate maculopapular rash, but severe skin reactions, including toxic epidermal necrolysis, have also been reported.
