Vitamin K Excess

(Vitamin K Toxicity)

ByLarry E. Johnson, MD, PhD, University of Arkansas for Medical Sciences
Reviewed/Revised Nov 2022
VIEW PROFESSIONAL VERSION

    Vitamin K toxicity is rare but is most common in formula-fed infants. 

    Vitamin K has two forms:

    • Phylloquinone: This form occurs in plants and is consumed in the diet. It is absorbed better when it is consumed with fat. Phylloquinone is not toxic, even in large amounts.

    • Menaquinone: This form is produced by bacteria in the intestine, but only small amounts of it are produced. In some countries, this form is used for supplementation.

    Vitamin K is necessary for normal blood clotting. It is also needed for healthy bones and other tissues.

    The effects of vitamin K toxicity can include anemia due to rupture of red blood cells and jaundice. Jaundice in newborns can cause kernicterus (a type of brain damage). 

    (See also Overview of Vitamins.)

    quizzes_lightbulb_red
    Test your KnowledgeTake a Quiz!
    Download the free MSD Manual App iOS ANDROID
    Download the free MSD Manual App iOS ANDROID
    Download the free MSD Manual App iOS ANDROID