Glycopeptides and lipoglycopeptides are antibiotics used to treat complicated and/or serious infections caused by gram-positive bacteria.
Glycopeptides and lipoglycopeptides include the following:
Teicoplanin
Most bacteria have an outer covering (cell wall) that protects them. Glycopeptides and lipoglycopeptides work by preventing gram-positive bacteria from forming this cell wall, resulting in the death of the bacteria.
Glycopeptides and Lipoglycopeptides
Drug | Common Uses* | Some Potential Side Effects |
|---|---|---|
Complicated skin infections due to susceptible gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) | Gastrointestinal upset Metallic taste Foamy urine Flushing and itching of the face, neck, and shoulders† | |
Complicated skin infections due to susceptible bacteria, including MRSA | Gastrointestinal upset Metallic taste Foamy urine Headache Flushing and itching of the face, neck, and shoulders† | |
Teicoplanin‡ | Serious infections, especially those due to susceptible gram-positive bacteria, including MRSA | Kidney damage Hearing loss and deafness A decrease in the platelet and white blood cell counts Flushing and itching of the face, neck, and shoulders† |
Serious infections, especially those due to susceptible gram-positive bacteria , including MRSA | Gastrointestinal upset Metallic taste Foamy urine Kidney damage Dizziness A decrease in the platelet count Flushing and itching of the face, neck, and shoulders† | |
Serious infections, especially those due to susceptible gram-positive bacteria, including MRSA Clostridioides difficile-induced colitis (given by mouth) | Flushing and itching of the face, neck, and shoulders† Kidney damage Hearing loss A decrease in white blood cell and platelet counts | |
* These drugs are given by injection into a vein except where noted. | ||
† These side effects are usually relieved by slowing the infusion. | ||
‡ Teicoplanin is currently not available in the United States. | ||
(See also Overview of Antibiotics.)
Use of Glycopeptides and Lipoglycopeptides During Pregnancy and Breastfeeding
C. difficile–induced diarrhea in pregnant women. (See also Drug Use During Pregnancy.)
Use of glycopeptides and lipoglycopeptides during breastfeeding is discouraged. (See also Drug Use During Breastfeeding.)
