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Legg-Calvé-Perthes Disease

By

Frank Pessler

, MD, PhD, Helmholtz Centre for Infection Research

Last full review/revision Oct 2020| Content last modified Oct 2020
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Legg-Calvé-Perthes disease involves destruction of the hip in children.

  • This disease is caused by a poor blood supply to the upper growth plate of the thighbone near the hip joint.

  • Typical symptoms include hip pain and trouble walking.

  • The diagnosis is based on x-rays and sometimes magnetic resonance imaging.

  • Treatment includes immobilization of the hip and bed rest.

Legg-Calvé-Perthes disease develops most commonly among boys between the ages of 5 and 10. The disease usually affects only one leg. About 10% of children have a relative who has the disease. It is caused by a poor blood supply to the upper growth plate Overview of Bone Disorders in Children Bone disorders can be caused by injury, infection, or cancer, be inherited, occur as part of a child’s growth, or occur for no known reason. Some bone disorders can cause pain and difficulty... read more of the thighbone (femur) near the hip joint. The poor blood supply causes the end of the thigh bone to die and collapse (avascular necrosis or osteonecrosis Osteonecrosis Osteonecrosis is the death of a segment of bone caused by an impaired blood supply. Osteonecrosis can be caused by an injury or can occur spontaneously. Typical symptoms include pain, limited... read more ). The reason for the poor blood supply in Legg-Calvé-Perthes disease is not known. Other problems also can interrupt blood supply to the growth plates. Such problems include sickle cell disease Sickle Cell Disease Sickle cell disease is an inherited genetic abnormality of hemoglobin (the oxygen-carrying protein found in red blood cells) characterized by sickle (crescent)-shaped red blood cells and chronic... read more Sickle Cell Disease and taking corticosteroid drugs. However, hip damage from these and other known causes is not considered Legg-Calvé-Perthes disease.

The Femur: Part of the Hip

The Femur: Part of the Hip Joint

Symptoms of Legg-Calvé-Perthes Disease

Legg-Calvé-Perthes disease can cause severe hip damage without causing significant symptoms at first. The severe damage may, however, lead to permanent arthritis of the hip. The first symptom of Legg-Calvé-Perthes disease often is pain in the hip joint and trouble walking. Pain begins gradually and progresses slowly. The pain tends to worsen when moving the hip or walking. Some children complain of pain only in the knee. A limp can develop, sometimes before the child has much pain. Eventually, joint movement becomes limited, and the thigh muscles may become wasted (atrophied) from lack of use.

Diagnosis of Legg-Calvé-Perthes Disease

  • Usually x-rays

  • Sometimes magnetic resonance imaging (MRI)

Doctors take x-rays of the child's skeleton if the disorder runs in the child's family or both of the child's legs are affected. These x-rays are taken to rule out hereditary disorders of the skeleton.

Blood tests are done to rule out other disorders. Doctors try to determine whether the symptoms resulted from an injury.

Prognosis of Legg-Calvé-Perthes Disease

Young children and children who have less damage when they are diagnosed have the best outcome.

Treatment of Legg-Calvé-Perthes Disease

  • Bed rest and immobilization of the hip

  • Sometimes surgery

Treatment of Legg-Calvé-Perthes disease includes prolonged bed rest and immobilization of the hip (for example, with a cast or splint). The choice of treatment depends on the child's age and amount of bone damage. Sometimes the partial immobilization provided by bed rest is sufficient. However, sometimes nearly total immobilization using traction, slings, plaster casts, or splints for 12 to 18 months is necessary. Such treatments keep the legs rotated outward.

If a child is over age 6 and has moderate or severe bone destruction, surgery may be helpful.

Even without treatment, Legg-Calvé-Perthes disease usually gets better, but it takes longer, usually 2 to 3 years, and there is an increased risk of hip arthritis developing later in life.

Treatment with bisphosphonates (drugs that help increase bone density) has been effective, but more studies are needed.

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