Disease |
Before the Vaccine Was Developed* |
Cases Reported in 2017 or 2016† ‡ |
21,053 |
0 |
|
Haemophilus influenzae type b infection (in children under 5 years) |
20,000 (estimated) |
33 |
117,333 (estimated) |
An estimated 4,000† |
|
Hepatitis B (acute) |
66,232 (estimated) |
An estimated 20,900† |
530,217 |
120 |
|
162,344 |
6,109 |
|
Pertussis (whooping cough) |
200,752 |
18,975 |
Pneumococcal infections that are severe—in all age groups |
63,067 (estimated) |
An estimated 30,400† |
Pneumococcal infections that are severe—in children under 5 years |
16,069 (estimated) |
An estimated 1,700† |
Polio that causes paralysis |
16,316 |
0 |
Rotavirus infections that required hospitalization—in children under 3 years |
62,500 (estimated) |
An estimated 30,625† |
47,745 |
7 |
|
29,005 |
0 |
|
580 |
33 |
|
Varicella (chickenpox) |
4,085,120 (estimated) |
An estimated 102,128† |
* The average number of cases in the United States each year during the 20th century. |
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† These numbers are from 2016. |
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‡ The number of cases reported in the United States. |
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Adapted from Appendix E: Data and statistics: Impact of vaccines in the 20th and 21st centuries. In Epidemiology and Prevention of Vaccine-Preventable Diseases: The Pink Book, edited by Hamborsky J, Kroger A, and Wolfe S. Centers for Disease Control and Prevention, Washington D.C. Public Health Foundation, 2015, p. E-5. Available at the Centers for Disease Control and Prevention. |