Merck Manual

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Some Serious Adverse Drug Reactions

Some Serious Adverse Drug Reactions

Adverse Drug Reaction

Types of Drugs

Examples

Anemia (resulting from decreased production or increased destruction of red blood cells)

Certain antibiotics

Chloramphenicol

Drugs used to treat malaria or tuberculosis in people with G6PD enzyme deficiency

Chloroquine

Isoniazid

Primaquine

Angioedema (swelling of the lips, tongue, and throat causing difficulty breathing)

ACE inhibitors

Captopril

Enalapril

Lisinopril

Proton pump inhibitors

Esomeprazole

Lansoprazole

Omeprazole

Birth control drugs (all forms including patches and pills)

Drospirenone/ethinyl estradiol

Norelgestromin/ethinyl estradiol

Confusion and drowsiness

Sedatives, including many antihistamines

Diphenhydramine

Antidepressants (especially in older people)

Amitriptyline

Imipramine

Decreased production of white blood cells, with increased risk of infection

Certain antipsychotic drugs

Clozapine

Chemotherapy drugs

Cyclophosphamide

Mercaptopurine

Methotrexate

Vinblastine

Some drugs used to treat thyroid disorders

Propylthiouracil

NSAIDs (repeated use of excessive doses)

Ibuprofen

Naproxen

Aminoglycoside antibiotics

Gentamicin

Tobramycin

Some chemotherapy drugs

Cisplatin

Methotrexate

Antifungals

Amphotericin B

Some antibiotics

Gentamicin

Tetracycline (outdated)

Some analgesics

Acetaminophen (use of excessive doses)

Some drugs used to treat tuberculosis

Isoniazid

Iron supplements (in excessive amounts)

Antidepressants

Duloxetine

Antibiotics

Tetracycline

Muscle tissue destruction (rhabdomyolysis)

Statins

Atorvastatin

Simvastatin

Stomach or intestinal ulcers (with or without bleeding)

NSAIDs

Aspirin

Ibuprofen

Naproxen

Anticoagulants

Heparin

Warfarin

Bisphosphonates

Alendronate

Risedronate

Some antibiotics

Penicillins

Quinolones

Anticonvulsants

Phenytoin

Valproic acid

Antiarrhythmics

Amiodarone

Procainamide

Sotalol

Antipsychotics

Chlorpromazine

Haloperidol

Lithium

ACE = angiotensin-converting enzyme; G6PD = glucose-6-phosphate dehydrogenase; NSAIDs = nonsteroidal anti-inflammatory drugs.