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St. John’s wort may reduce the effectiveness of these drugs in reducing anxiety and may increase the risk of side effects such as drowsiness.
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St. John’s wort may reduce blood levels of cyclosporine, making it less effective, with potentially dangerous results (such as rejection of an organ transplant).
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St. John’s wort may reduce blood levels of digoxin, making it less effective, with potentially dangerous results.
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St. John’s wort may reduce iron absorption.
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Monoamine oxidase inhibitors (MAOIs)
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St. John’s wort may intensify the effects of MAOIs, possibly causing very high blood pressure that requires emergency treatment.
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Nonnucleoside reverse transcriptase inhibitors
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St. John’s wort increases the metabolism of these drugs, reducing their effectiveness.
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St. John’s wort increases the metabolism of these drugs, reducing their effectiveness.
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St. John’s wort decreases serum concentrations of omeprazole, reducing its effectiveness.
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Photosensitizing drugs (such as amiodarone, naproxen, sulfonylureas [such as glipizide], and sulfonamide antibiotics)
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When taken with these drugs, St. John’s wort may increase the risk of sun sensitivity.
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Protease inhibitors (such as indinavir or saquinavir), which are used to treat human immunodeficiency virus [HIV] infection
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St. John’s wort may reduce blood levels of protease inhibitors, making them less effective.
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Selective serotonin reuptake inhibitors (SSRIs, such as fluoxetine, paroxetine, and sertraline)
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St. John’s wort may intensify the effects of these drugs.
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Tricyclic antidepressants
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St. John’s wort may decrease the effects of these drugs.
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St. John’s wort may reduce blood levels of warfarin, making it less effective and clot formation more likely.
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