| | St. John’s wort may reduce the effectiveness of these drugs in reducing anxiety and may increase the risk of side effects such as drowsiness. |
| | St. John’s wort may reduce blood levels of cyclosporine, making it less effective, with potentially dangerous results (such as rejection of an organ transplant). |
| | St. John’s wort may reduce blood levels of digoxin, making it less effective, with potentially dangerous results. |
| | St. John’s wort may reduce iron absorption. |
Monoamine oxidase inhibitors (MAOIs) | St. John’s wort may intensify the effects of MAOIs, possibly causing very high blood pressure that requires emergency treatment. |
Nonnucleoside reverse transcriptase inhibitors | St. John’s wort increases the metabolism of these drugs, reducing their effectiveness. |
| | St. John’s wort increases the metabolism of these drugs, reducing their effectiveness. |
| | St. John’s wort decreases serum concentrations of omeprazole, reducing its effectiveness. |
Photosensitizing drugs (such as amiodarone, naproxen, sulfonylureas [such as glipizide], and sulfonamide antibiotics) | When taken with these drugs, St. John’s wort may increase the risk of sun sensitivity. |
Protease inhibitors (such as indinavir or saquinavir), which are used to treat human immunodeficiency virus [HIV] infection | St. John’s wort may reduce blood levels of protease inhibitors, making them less effective. |
Selective serotonin reuptake inhibitors (SSRIs, such as fluoxetine, paroxetine, and sertraline) | St. John’s wort may intensify the effects of these drugs. |
Tricyclic antidepressants | St. John’s wort may decrease the effects of these drugs. |
| | St. John’s wort may reduce blood levels of warfarin, making it less effective and clot formation more likely. |
