Table: Some Causes of Excessive Bleeding - Merck Manuals Consumer Version

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Some Causes of Excessive Bleeding

Some Causes of Excessive Bleeding

Cause	Examples
Platelet disorders
Decreased number of platelets	Aplastic anemia Cirrhosis if the spleen is enlarged DIC if it progresses rapidly Drugs that can trigger destruction of platelets (including heparin, quinidine, quinine, sulfonamides, sulfonylureas, or rifampin) Hemolytic-uremic syndrome HIV infection Immune thrombocytopenia Leukemia Thrombotic thrombocytopenic purpura
Increased number of platelets (which often causes excessive clotting but sometimes causes excessive bleeding)	Primary thrombocythemia
Inadequate platelet function	Drugs that can cause platelets to malfunction (including aspirin or other NSAIDs) Chronic kidney disease Multiple myeloma Von Willebrand disease
Clotting disorders
Acquired	Anticoagulants (drugs that inhibit clotting) including heparin, warfarin, or DOACs (including dabigatran, apixaban, edoxaban, and rivaroxaban) DIC if it progresses slowly Liver disease Vitamin K deficiency
Hereditary	Hemophilia
Blood vessel disorders
Acquired	Immunoglobulin A–associated vasculitis Vitamin C deficiency
Hereditary	Connective tissue disorders (such as Marfan syndrome) Hereditary hemorrhagic telangiectasia Von Willebrand disease
DIC = disseminated intravascular coagulation; DOAC = direct oral anticoagulant; HIV = human immunodeficiency virus; NSAIDs = nonsteroidal anti-inflammatory drugs; vWF = von Willebrand factor.